Boampong J N, Ameyaw E O, Aboagye B, Asare K, Kyei S, Donfack J H, Woode E
Department of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast, Ghana.
J Parasitol Res. 2013;2013:356107. doi: 10.1155/2013/356107. Epub 2013 Jul 18.
Efforts have been intensified to search for more effective antimalarial agents because of the observed failure of some artemisinin-based combination therapy (ACT) treatments of malaria in Ghana. Xylopic acid, a pure compound isolated from the fruits of the Xylopia aethiopica, was investigated to establish its attributable prophylactic, curative antimalarial, and antipyretic properties. The antimalarial properties were determined by employing xylopic acid (10-100 mg/kg) in ICR mice infected with Plasmodium berghei. Xylopic acid exerted significant (P < 0.05) effects on P. berghei infection similar to artemether/lumefantrine, the standard drug. Furthermore, it significantly (P < 0.05) reduced the lipopolysaccharide- (LPS-) induced fever in Sprague-Dawley rats similar to prednisolone. Xylopic acid therefore possesses prophylactic and curative antimalarial as well as antipyretic properties which makes it an ideal antimalarial agent.
由于在加纳观察到一些基于青蒿素的联合疗法（ACT）治疗疟疾失败，人们加大了寻找更有效抗疟药物的力度。对从埃塞俄比亚木瓣树果实中分离出的纯化合物木瓣树酸进行了研究，以确定其预防、治疗疟疾和退热的特性。通过在感染伯氏疟原虫的ICR小鼠中使用木瓣树酸（10 - 100毫克/千克）来测定其抗疟特性。木瓣树酸对伯氏疟原虫感染产生了与标准药物蒿甲醚/本芴醇相似的显著（P < 0.05）效果。此外，它与泼尼松龙相似，能显著（P < 0.05）降低脂多糖（LPS）诱导的斯普拉格 - 道利大鼠发热。因此，木瓣树酸具有预防和治疗疟疾以及退热特性，这使其成为一种理想的抗疟药物。
