Cincinnati Children's Research Foundation, Cincinnati, OH, United States.
Vaccine. 2013 Aug 28;31 Suppl 4:D27-30. doi: 10.1016/j.vaccine.2013.02.031.
The strategy of prenatal maternal immunization to protect the pregnant woman and her infant was first used with tetanus toxoid, when it was recognized that young infants had very high rates of tetanus disease, well before the age when infant immunizations are provided. Antenatal immunization has now been recommended and utilized for additional vaccines to prevent infections in pregnancy and the young infant. There are several issues to consider which are unique to the strategy of antenatal immunization. The first is that immunization of the pregnant woman will affect the woman who receives the vaccine, her developing fetus, and the young infant for several months after delivery. For this discussion, we will consider the availability of data for the maternal-fetal-infant triad in 4 aspects: This discussion will review available data from vaccines for prevention of tetanus, pneumococcal, influenza and pertussis infections used in antenatal maternal immunization programs.
产前孕妇免疫接种策略最初用于破伤风类毒素，当时人们认识到，婴幼儿患破伤风病的比率非常高，远在婴幼儿接种疫苗之前。现在已经推荐和利用产前免疫接种来预防妊娠和婴幼儿感染其他疫苗。该策略有几个独特的问题需要考虑。首先，孕妇接种疫苗将影响接受疫苗的妇女、她正在发育的胎儿和分娩后几个月的婴儿。在本次讨论中，我们将从母婴婴儿三联体的角度考虑以下 4 个方面的数据可用性：本讨论将回顾预防破伤风、肺炎球菌、流感和百日咳感染的疫苗在产前孕妇免疫接种计划中的可用数据。
