Embi P J
The Ohio State University, 3190 Graves Hall, 333 W. 10th Ave, Columbus, OH 43210, USA. E-mail:
Yearb Med Inform. 2013;8:178-84.
To provide a survey of the field of clinical research informatics (CRI), focusing in particular on significant developments over the past 3 years and the insights they provide about the progress and state of the field.
An iterative "scoping review" of the literature published in scientific journals and conference proceedings that are relevant to CRI, from late 2009 to early 2013.
212 articles were identified, and 64 were selected to illustrate recent advances in the field. Based on those, six categories of CRI activity were identified: Data and Knowledge Management, Discovery and Standards; Clinical Data Re-Use for Research; Researcher Support and Resources; Participant Recruitment; Patients/Consumers and CRI; Policy, Regulatory and Fiscal Matters.
This survey demonstrates that the field of CRI has matured and is now well established. The ongoing work is essential to overcome many of the challenges the clinical research enterprise is facing and more work is needed. Even as work continues to establish necessary infrastructure, methods, and best practices, CRI researchers should strive for more rigorous study designs to evaluate the impacts of the work in the field. There is little doubt that the field is poised for rapid growth, and that the CRI literature will continue to reflect that growth in years to come.
对临床研究信息学（CRI）领域进行综述，特别关注过去3年的重大进展以及这些进展所提供的关于该领域进展和现状的见解。
对2009年末至2013年初发表在与CRI相关的科学期刊和会议论文集上的文献进行迭代式“范围综述”。
共识别出212篇文章，选取64篇来说明该领域的近期进展。基于这些文章，确定了CRI活动的六个类别：数据与知识管理、发现与标准；临床数据用于研究的再利用；研究人员支持与资源；参与者招募；患者/消费者与CRI；政策、监管与财政事务。
本次综述表明CRI领域已经成熟且现已确立。正在进行的工作对于克服临床研究企业面临的许多挑战至关重要，并且还需要更多工作。即使在继续建立必要的基础设施、方法和最佳实践的同时，CRI研究人员也应努力采用更严格的研究设计来评估该领域工作的影响。毫无疑问，该领域有望实现快速增长，并且CRI文献在未来几年将继续反映这种增长。
