一例儿童红白血病的细胞遗传学研究。

Cytogenetic study of a case of childhood erythroleukemia.

作者信息

Duarte M H, Tone L G, Soares L R, dos Santos S A

机构信息

Department of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil.

出版信息

Cancer Genet Cytogenet. 1990 Oct 1;49(1):25-30. doi: 10.1016/0165-4608(90)90160-c.

DOI:10.1016/0165-4608(90)90160-c

PMID:2397470

Abstract

We report a case of childhood erythroleukemia diagnosed by French-American-British Cooperative group (FAB) and by cytogenetic analysis of bone marrow cells. The following major chromosome anomalies were detected: hyperdiploidy with a modal number of 49, three markers consisting of translocations between chromosomes 3, 9, 20, and 15, deletion of the long arm of chromosome 16 (q22----qter), and karyotype instability. These changes were compared with others reported in the literature and discussed in terms of their importance for diagnostic confirmation.

摘要

我们报告一例儿童红白血病病例，该病例由法美英协作组（FAB）诊断，并通过对骨髓细胞进行细胞遗传学分析确诊。检测到以下主要染色体异常：超二倍体，众数为49，三个标记，包括3号、9号、20号和15号染色体之间的易位，16号染色体长臂（q22----qter）缺失，以及核型不稳定。将这些变化与文献中报道的其他变化进行了比较，并就其对诊断确认的重要性进行了讨论。