Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Retina. 2014 Apr;34(4):741-8. doi: 10.1097/IAE.0b013e3182a48917.
To determine the relationship between the retinal morphologic changes and concentrations of intravitreal cytokines in eyes with diabetic macular edema.
A retrospective comparative study was performed. The preoperative optical coherence tomography images were evaluated to determine the presence of serous retinal detachments (SRDs), retinal cystic changes, and retinal swelling. The concentrations of vascular endothelial growth factor, interleukin (IL)-6, and IL-8 in vitreous samples collected during vitrectomy were determined. The correlations between optical coherence tomography parameters, other clinical factors, and the concentration of cytokines were calculated.
Fifty-two eyes (52 patients) were investigated. An SRD was found in 19 of the 52 eyes (36.5%). Multivariate regression analysis showed that IL-6 was the only factor significantly associated with the presence of an SRD (P = 0.001; odds ratio, 1.268; 95% confidence interval, 1.105-1.452). The other morphologic changes, such as retinal cystic changes and retinal swellings, were not significantly associated with the concentrations of intravitreal cytokines.
The significant association of SRD with intravitreal IL-6 indicates that inflammation may play an important role in the development of SRD in diabetic macular edema.
探讨糖尿病黄斑水肿患者眼内液中细胞因子浓度与视网膜形态变化的关系。
回顾性对比研究。术前应用光学相干断层扫描（OCT）评估是否存在浆液性视网膜脱离（SRD）、视网膜囊样改变和视网膜肿胀。通过玻璃体切割术采集玻璃体标本，检测血管内皮生长因子（VEGF）、白细胞介素（IL）-6 和 IL-8 的浓度。计算 OCT 参数、其他临床因素与细胞因子浓度之间的相关性。
52 只眼（52 例患者）纳入研究。52 只眼中 19 只（36.5%）存在 SRD。多变量回归分析显示，IL-6 是唯一与 SRD 存在显著相关的因素（P=0.001；比值比，1.268；95%置信区间，1.105-1.452）。其他形态改变，如视网膜囊样改变和视网膜肿胀，与眼内液细胞因子浓度无显著相关性。
SRD 与眼内液 IL-6 浓度显著相关，提示炎症可能在糖尿病黄斑水肿 SRD 的发生发展中起重要作用。
