Department of Clinical Laboratory, Taizhou Municipal Hospital, Taizhou, Zhejiang, China.
PLoS One. 2013 Aug 19;8(8):e71901. doi: 10.1371/journal.pone.0071901. eCollection 2013.
Genome-wide association studies have shown that variance in the fat mass- and obesity- associated gene (FTO) is associated with risk of obesity in Europeans and Asians. Since obesity is associated with an increased risk of cardiovascular disease (CVD), several studies have investigated the association between variant in the FTO gene and CVD risk, with inconsistent results. In this study, we performed a meta-analysis to clarify the association of rs9939609 variant (or its proxies [r (2)>0.90]) in the FTO gene with CVD risk.
Published literature from PubMed and Embase was retrieved. Pooled odds ratios with 95% confidence intervals were calculated using the fixed- or random- effects model.
A total of 10 studies (comprising 19,153 CVD cases and 103,720 controls) were included in the meta-analysis. The results indicated that the rs9939609 variant was significantly associated with CVD risk (odds ratio = 1.18, 95% confidence interval = 1.07-1.30, p = 0.001 [Z test], I (2) = 80.6%, p<0.001 [heterogeneity]), and there was an insignificant change after adjustment for body mass index (BMI) and other conventional CVD risk factors (odds ratio = 1.16, 95% confidence interval = 1.05-1.27, p = 0.003 [Z test], I (2) = 75.4%, p<0.001 [heterogeneity]).
The present meta-analysis confirmed the significant association of the rs9939609 variant in the FTO gene with CVD risk, which was independent of BMI and other conventional CVD risk factors.
全基因组关联研究表明，肥胖相关基因（FTO）的变异与欧洲人和亚洲人的肥胖风险相关。由于肥胖与心血管疾病（CVD）风险增加相关，因此有几项研究调查了 FTO 基因变异与 CVD 风险之间的关联，但结果不一致。在这项研究中，我们进行了荟萃分析以阐明 FTO 基因中 rs9939609 变异（或其代理物[r (2)>0.90]）与 CVD 风险的关联。
从 PubMed 和 Embase 检索已发表的文献。使用固定或随机效应模型计算合并的优势比及其 95%置信区间。
共有 10 项研究（包括 19153 例 CVD 病例和 103720 例对照）纳入荟萃分析。结果表明，rs9939609 变异与 CVD 风险显著相关（优势比=1.18，95%置信区间=1.07-1.30，p=0.001[Z 检验]，I (2)=80.6%，p<0.001[异质性]），并且在调整体重指数（BMI）和其他传统 CVD 危险因素后，这种相关性没有显著变化（优势比=1.16，95%置信区间=1.05-1.27，p=0.003[Z 检验]，I (2)=75.4%，p<0.001[异质性]）。
本荟萃分析证实了 FTO 基因中 rs9939609 变异与 CVD 风险之间存在显著关联，这种关联独立于 BMI 和其他传统 CVD 危险因素。
