Frazier-Wood Alexis C, Borecki Ingrid B, Feitosa Mary F, Hopkins Paul N, Smith Caren E, Arnett Donna K
Division of Epidemiology, Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, TX.
Int J Sport Nutr Exerc Metab. 2014 Feb;24(1):59-69. doi: 10.1123/ijsnem.2013-0117. Epub 2013 Aug 26.
Time spent in sedentary activities (such as watching television) has previously been associated with several risk factors for cardiovascular disease (CVD) such as increased low-density lipoprotein cholesterol (LDL-C). Little is known about associations with lipoprotein subfractions. Using television and computer screen time in hours per day as a measure of sedentary time, we examined the association of screen time with lipoprotein subfractions.
Data were used from men and women forming the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study population. Mixed linear models specified lipoprotein measures as the outcome, and screen time as the predictor for fourteen lipoprotein subfraction measures, and included age, smoking status, pedigree, and fat, carbohydrate daily alcohol and energy intake as covariates. Analyses were run separately for men (n = 623) and women (n = 671). A step-down Bonferroni correction was applied to results. The analysis was repeated for significant results (p < .05), additionally controlling for body mass index (BMI) and moderate and vigorous physical activity.
Linear models indicated that screen time was associated with five lipoprotein parameters in women: the concentration of large VLDL particles (p = .01), LDL particle number (p = .01), concentration of small LDL particles (p = .04), the concentration of large HDL particles (p = .04), and HDL diameter (p = .02). All associations remained after controlling for moderate or vigorous physical activity and BMI.
We show that sedentary time is associated with lipoprotein measures, markers of cardiometabolic disease, independently of physical activity and BMI, in women but not men.
此前，久坐活动（如看电视）的时长已与心血管疾病（CVD）的多种风险因素相关，如低密度脂蛋白胆固醇（LDL-C）升高。而关于脂蛋白亚组分的关联情况，人们知之甚少。我们以每天看电视和使用电脑的时长作为久坐时间的衡量指标，研究了屏幕使用时间与脂蛋白亚组分之间的关联。
使用了参与降脂药物和饮食遗传学网络（GOLDN）研究人群的男性和女性的数据。混合线性模型将脂蛋白测量值指定为结果变量，屏幕使用时间作为14种脂蛋白亚组分测量值的预测变量，并将年龄、吸烟状况、家系以及脂肪、碳水化合物、每日酒精摄入量和能量摄入作为协变量。分别对男性（n = 623）和女性（n = 671）进行分析。对结果应用逐步Bonferroni校正。对显著结果（p <.05）重复进行分析，另外控制体重指数（BMI）以及中度和剧烈身体活动。
线性模型表明，屏幕使用时间与女性的5种脂蛋白参数相关：大极低密度脂蛋白（VLDL）颗粒浓度（p = 0.01）、低密度脂蛋白颗粒数量（p = 0.01）、小低密度脂蛋白颗粒浓度（p = 0.04）、大高密度脂蛋白（HDL）颗粒浓度（p = 0.04）和高密度脂蛋白直径（p = 0.02）。在控制了中度或剧烈身体活动和BMI后，所有关联仍然存在。
我们发现，久坐时间与脂蛋白测量值（心血管代谢疾病的标志物）相关，在女性中独立于身体活动和BMI，但在男性中并非如此。
