Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.
Chin Med J (Engl). 2013 Aug;126(16):3006-12.
CKLF-like MARVEL transmembrane domain-containing 7 (CMTM7) located at 3p22.3, is a frequent deletion site and a tumor suppressor gene (TSG) locus in many cancer, which suggests CMTM7 may be a potential TSG. The aim of this study was to investigate the correlations of CMTM7 expression and survival rate in patients with non-smallcell lung cancer (NSCLC).
Surgical specimens of 180 cases with pathologically confirmed NSCLC were grouped into 18 tissue microarray slides. CMTM7 expression in these specimens were detected by immunohistochemistry staining and representative cases were confirmed by Western blotting. Univariate and multivariate analyses were performed to identify the association of CMTM7 expression with pathological features and survival of patients with NSCLC.
A total of 78.9% of the 180 patients had variations of CMTM7 protein expression, either up-regulated or down-regulated. Univariate analysis showed that the patients' survival rate after surgery was highly correlated with CMTM7 expression (P = 0.0091). In addition, prognostic factors were examined by multivariate Cox regression analysis, and results suggested that CMTM7 expression was a unique prognostic factor in NSCLC survival.
The CMTM7 expression may be related to survival of patients with NSCLC and a unique prognostic factor. CMTM7 may play an important role in NSCLC development.
CKLF 样 MARVEL 跨膜结构域包含 7（CMTM7）位于 3p22.3，是许多癌症中频繁缺失的位点和肿瘤抑制基因（TSG）基因座，这表明 CMTM7 可能是一个潜在的 TSG。本研究旨在探讨 CMTM7 在非小细胞肺癌（NSCLC）患者中的表达与生存率的相关性。
将 180 例经病理证实的 NSCLC 手术标本分为 18 个组织微阵列载玻片。采用免疫组织化学染色法检测这些标本中 CMTM7 的表达，并采用 Western blot 法对代表性病例进行验证。采用单因素和多因素分析来确定 CMTM7 表达与 NSCLC 患者的病理特征和生存的相关性。
180 例患者中，共有 78.9%的患者存在 CMTM7 蛋白表达的变化，表现为上调或下调。单因素分析表明，患者术后的生存率与 CMTM7 表达高度相关（P = 0.0091）。此外，通过多因素 Cox 回归分析对预后因素进行了检验，结果表明 CMTM7 表达是非小细胞肺癌患者生存的一个独特的预后因素。
CMTM7 表达可能与非小细胞肺癌患者的生存率相关，是一个独特的预后因素。CMTM7 可能在非小细胞肺癌的发生发展中发挥重要作用。
