Li Jie, Wang Xiaozi, Wang Xiaoning, Liu Yan, Zheng Na, Xu Pengwei, Zhang Xianghong, Xue Liying
Department of Hematology, Hebei General Hospital, Shijiazhuang, 050000, People's Republic of China.
Laboratory of Pathology, Hebei Medical University, Shijiazhuang, 050000, People's Republic of China.
Cancer Manag Res. 2022 Apr 26;14:1551-1563. doi: 10.2147/CMAR.S358963. eCollection 2022.
Gastrointestinal tract cancers are a highly heterogeneous group of malignant diseases, contributing significantly to the burden of death worldwide. Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTMs) plays important roles in cancer development and progression. Since the first member was cloned, there have been abundant studies on the relationships between the CMTM family and human cancers. It has been reported that the CMTM family has a large potential prognostic value for multiple cancers. Meanwhile, upregulated or downregulated expression of the family members was related to advanced tumor stage, metastasis, and overall survival. Studies have also reported that these proteins play critical roles in antitumor immunity. We performed a systematic review to sum up the latest advances of CMTM family' roles in gastrointestinal tract cancers, with a primary focus on hepatocellular carcinoma and gastric carcinoma.
胃肠道癌症是一组高度异质性的恶性疾病，在全球死亡负担中占很大比例。趋化因子样因子（CKLF）样含MARVEL跨膜结构域家族（CMTMs）在癌症发生和发展中起重要作用。自第一个成员被克隆以来，已有大量关于CMTM家族与人类癌症之间关系的研究。据报道，CMTM家族对多种癌症具有很大的潜在预后价值。同时，家族成员的表达上调或下调与肿瘤晚期、转移及总生存期相关。研究还报道，这些蛋白在抗肿瘤免疫中起关键作用。我们进行了一项系统综述，以总结CMTM家族在胃肠道癌症中作用的最新进展，主要关注肝细胞癌和胃癌。
