Bioinformatics-Based Discovery of -Like Transmembrane Member 5 as a Novel Biomarker for Breast Cancer.

Chemokine-like factor (CKLF)-like transmembrane members () represent a novel protein family linking the chemokine and transmembrane-4 superfamily families, which potentially play several roles in diverse physiological and pathological processes. The detailed functions and underlying molecular mechanisms of remain elusive in breast cancer. Herein, we performed a comprehensive bioinformatic analysis to investigate the prognostic effect, potential functions, and biomolecular regulatory network of in breast cancer. The mRNA expression level of , in particular, was significantly downregulated in breast cancer; moreover, high mRNA expression level of was significantly associated with better relapse-free survival. DNA promoter hypermethylation of was negatively correlated with its mRNA expression levels. Furthermore, strongly associated with pathway in MARVEL domains, chemotaxis, cytokines, transmembrane structures, and integral component of membrane. For example, genes related to MARVEL domains, transmembrane structures, and chemokines were significantly enriched. Our findings indicate that can be used as a prognostic biomarker and potential therapeutic target for breast cancer.