Sireeratawong Seewaboon, Khonsung Parirat, Nanna Urarat, Vannasiri Supaporn, Lertprasertsuke Nirush, Singhalak Tipaya, Soonthornchareonnon Noppamas, Jaijoy Kanjana
Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.
Afr J Tradit Complement Altern Med. 2012 Jul 1;9(4):519-29. doi: 10.4314/ajtcam.v9i4.8. eCollection 2012.
Learng Pid Samud (LPS) recipe is a traditional remedy in Thai folk medicine to ease the common diarrhea. The anti-diarrheal potential of LPS recipe was herein examined in vitro using a guinea-pig ileum model. The LPS exerted an inhibitory effect on acetylcholine-induced smooth muscle contraction in the guinea pig ileum. Significantly, not only did the LPS reduce the total amount of feces in the induced diarrhea rats, but also the intestinal transit in the charcoal meal test. A single oral administration with the recipe at 5,000 mg/kg did not cause acute toxicity and the daily oral administration (1,000, 2,000 and 4,000 mg/kg) for 90 days in rats did not produce any toxic signs and symptoms. In conclusion, the Learng Pid Samud recipe remedy is evidently safe and effective for the anti-diarrheal treatment which supports its therapeutic uses in the alternative medicine.
Learng Pid Samud（LPS）配方是泰国传统民间医学中缓解常见腹泻的一种疗法。本文使用豚鼠回肠模型在体外研究了LPS配方的抗腹泻潜力。LPS对豚鼠回肠中乙酰胆碱诱导的平滑肌收缩具有抑制作用。值得注意的是，LPS不仅减少了诱导腹泻大鼠的粪便总量，还减少了炭末试验中的肠道转运。以5000mg/kg的剂量单次口服该配方不会引起急性毒性，并且在大鼠中每日口服（1000、2000和4000mg/kg）90天也未产生任何毒性体征和症状。总之，Learng Pid Samud配方疗法在抗腹泻治疗中显然是安全有效的，这支持了其在替代医学中的治疗用途。
