COPD 患者影响 PSA 值的内分泌紊乱特征。
Profile of endocrinological derangements affecting PSA values in patients with COPD.
机构信息
Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, 75 Micras Asias, Goudi, Athens 115 27, Greece.
出版信息
In Vivo. 2013 Sep-Oct;27(5):641-9.
BACKGROUND/AIM: Chronic obstractive pulmonary disease (COPD) in men has been associated with testosterone deficiency, known as the late-onset hypogonadism. Prostate cancer becomes more prevalent when testosterone values decline in males. We sought to determine endocrinological derangements that may affect PSA values in male patients with COPD.
MATERIALS AND METHODS
A total of 69 male patients with COPD and 82 healthy volunteers were divided into subgroups according to: their age: (i) ≤60 years and (ii) >60 years; or disease severity: (i) FEV1<50% and (ii) FEV1≥50% predicted.
RESULTS
There was a significant reduction in total and free testosterone in patients with COPD. Patients with COPD aged >60 years had significantly lower free PSA compared to the control group.
CONCLUSION
Alterations of the male hormonal status in COPD are related with older age (>60 years) and poorer lung function (FEV1<50% predicted). This may have implications for the use of the PSA-based screening tests in the elderly male population with COPD.
背景/目的：男性慢性阻塞性肺疾病（COPD）与睾丸激素缺乏有关，即迟发性性腺功能减退症。当男性睾丸激素值下降时，前列腺癌的发病率会更高。我们试图确定可能影响 COPD 男性患者 PSA 值的内分泌失调。
材料和方法
共 69 名 COPD 男性患者和 82 名健康志愿者根据以下标准分为亚组：年龄：（i）≤60 岁和（ii）>60 岁；或疾病严重程度：（i）FEV1<50%和（ii）FEV1≥50%预计值。
结果
COPD 患者的总睾酮和游离睾酮明显降低。年龄>60 岁的 COPD 患者的游离 PSA 明显低于对照组。
结论
COPD 男性的男性激素状态改变与年龄较大（>60 岁）和肺功能较差（FEV1<50%预计值）有关。这可能对基于 PSA 的老年 COPD 男性人群筛查试验的使用产生影响。
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