Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, 3052, Victoria, Australia.
J Mol Recognit. 2013 Oct;26(10):439-49. doi: 10.1002/jmr.2293.
The influenza surface glycoprotein hemagglutinin (HA) binds to sialylglycoproteins and sialylglycolipids on the surface of host cells. These sialyl-glycans, usually linked to galactose in either α2,6 or α2,3 configurations, are the receptors for the viral HA, the binding to which promotes viral attachment, membrane fusion, and internalization of the virus. This review examines all of the available receptor binding data on the influenza B HA and provides a structure recognition perspective for the receptor binding preferences of influenza B virus HA regional and egg-adapted variants. Overall, the review serves as an up-to-date compendium of the literature binding data, and the presented discussions assist the reader in reaching a consensus understanding of the receptor specificity determinants for the influenza B HA.
流感病毒表面糖蛋白血凝素（HA）与宿主细胞表面的唾液酸糖蛋白和唾液酸糖脂结合。这些唾液酸糖链通常与半乳糖以α2,6 或 α2,3 构型连接，是病毒 HA 的受体，病毒 HA 与这些受体的结合促进了病毒的附着、膜融合和内化。这篇综述检查了所有现有的关于乙型流感病毒 HA 的受体结合数据，并为乙型流感病毒 HA 的区域和鸡蛋适应变体的受体结合偏好提供了结构识别视角。总的来说，该综述是对文献结合数据的最新汇编，所呈现的讨论有助于读者达成对乙型流感病毒 HA 的受体特异性决定因素的共识理解。
