Bartolome Julian A, Khalloub Pablo, de la Sota Rodolfo Luzbel, Drillich Marc, Melendez Pedro G
Facultad de Ciencias Veterinarias, Universidad Nacional de La Pampa, Calles 5 y 116 S/N, General Pico, 6360, La Pampa, Argentina,
Trop Anim Health Prod. 2014 Jan;46(1):79-85. doi: 10.1007/s11250-013-0450-z. Epub 2013 Sep 1.
The objectives of this study were to evaluate the efficacy of (1) administering ceftiofur hydrochloride in dairy cows with calving-related disorders to prevent metritis and (2) a combination of GnRH and PGF2α for the treatment of clinical endometritis, under Argentinean dairy farming conditions. Cows at high risk (HRC) for metritis (dystocia, RFM >12 h postpartum, hypocalcaemia, twins, or stillbirth) were randomly assigned to receive either 1.1 mg/Kg of ceftiofur hydrochloride on three consecutive days (HRC treated group HRCT, n = 110) or remained untreated (HRC control group HRCC, n = 126). Cows with low risk (LRC, no calving-related disorders, n = 868) did not receive any treatment (LRC group, n = 868). All cows were examined for metritis between days 4 and 10 and for clinical endometritis between 24 and 30 days postpartum. The body condition score (BCS) was recorded at both examinations. Cows with endometritis at days 24 to 30 postpartum received either 1.5 mg of D-cloprostenol (PGF; n = 129) or 100 μg of GnRH followed by D-cloprostenol after 7 days (GnRH+PGF, n = 119). There was no overall effect of treatment on the incidence of metritis or on time to pregnancy. Treatment, however, reduced the incidence of metritis in cows with high BCS (HRCT = 24.0 %, HRCC = 38.5 %) but had no effect in cows with low BCS (HRCT = 38.7 %, HRCC = 37.5 %). The proportion of pregnant cows by days in milk was greater (P < 0.01) in LRC group compared with that of the HRCT and HRCC groups. No significant differences were found between groups PG and PG+GNRH. GnRH+PGF treatment, however, tended (P = 0.06) to increase pregnancy rate in cows with a moderate loss of BCS (76.5 vs 65.2 %) but tended to reduce pregnancy rate (54.5 vs 76.0 %) in cows with a more pronounced loss in BCS (>0.75 points).
本研究的目的是在阿根廷奶牛养殖条件下，评估（1）给患有与产犊相关疾病的奶牛注射盐酸头孢噻呋以预防子宫炎，以及（2）联合使用促性腺激素释放激素（GnRH）和前列腺素F2α（PGF2α）治疗临床子宫内膜炎的疗效。将患子宫炎高风险（HRC）奶牛（难产、产后直肠检查恶露排出时间>12小时、低血钙、双胎或死胎）随机分为连续三天每天接受1.1mg/kg盐酸头孢噻呋组（HRC治疗组HRCT，n = 110）或不治疗组（HRC对照组HRCC，n = 126）。低风险（LRC，无与产犊相关疾病，n = 868）奶牛不接受任何治疗（LRC组，n = 868）。所有奶牛在产后4至10天检查子宫炎，在产后24至30天检查临床子宫内膜炎。两次检查时均记录体况评分（BCS）。产后24至30天患有子宫内膜炎的奶牛，要么接受1.5mg氯前列醇（PGF；n = 129），要么接受100μg GnRH，7天后再接受氯前列醇（GnRH + PGF，n = 119）。治疗对子宫炎发病率或怀孕时间无总体影响。然而，治疗降低了高BCS奶牛的子宫炎发病率（HRCT = 24.0%，HRCC = 38.5%），但对低BCS奶牛无效（HRCT = 38.7%，HRCC = 37.5%）。与HRCT组和HRCC组相比，LRC组按产奶天数计算的怀孕奶牛比例更高（P < 0.01）。PG组和PG + GNRH组之间未发现显著差异。然而，GnRH + PGF治疗在BCS中度下降的奶牛中倾向于（P = 0.06）提高怀孕率（76.5%对65.2%），但在BCS下降更明显（>0.75分）的奶牛中倾向于降低怀孕率（54.5%对76.0%）。
