Instituto de Biología Molecular y Celular de Rosario (CONICET), Rosario, Argentina.
Area Virología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina.
J Gen Virol. 2013 Nov;94(Pt 11):2480-2488. doi: 10.1099/vir.0.055137-0. Epub 2013 Aug 30.
More than 170 human papillomavirus (HPV) types have been completely sequenced, curated and divided into five genera: Alphapapillomavirus, Betapapillomavirus, Gammapapillomavirus, Mupapillomavirus and Nupapillomavirus. With the application of PCR methods, hundreds of putative novel HPV types have been identified as PCR amplicons in mucosa and skin. However, at present there are no studies reporting a systematic search of the currently known L1 amplicons and their phylogenetic relationships. This survey revealed the existence of at least 202 different putative HPV types that are pending for full-genome characterization: five alphapapillomaviruses, 37 betapapillomaviruses, 159 gammapapillomaviruses and one mupapillomavirus. All potential viruses of the genera Alphapapillomavirus and Betapapillomavirus were grouped in the defined species, while 59 putative gammapapillomaviruses types were segregated in 21 unidentified putative species. These data highlight the need for progress in the identification of additional taxa of the family Papillomaviridae in order to elucidate the diversity, evolution and medical implications of these viruses.
已经对超过 170 种人类乳头瘤病毒（HPV）进行了完全测序、整理，并分为五个属：α乳头瘤病毒、β乳头瘤病毒、γ乳头瘤病毒、μ乳头瘤病毒和 ν乳头瘤病毒。通过应用 PCR 方法，已经在黏膜和皮肤中鉴定出数百种推定的新型 HPV 类型作为 PCR 扩增子。然而，目前尚无研究报告对现有已知的 L1 扩增子及其系统发育关系进行全面搜索。本调查显示，至少存在 202 种不同的推定 HPV 类型有待进行全基因组特征描述：5 种α乳头瘤病毒、37 种β乳头瘤病毒、159 种γ乳头瘤病毒和 1 种μ乳头瘤病毒。所有属的潜在病毒阿尔法乳头瘤病毒和β乳头瘤病毒都被分组在确定的物种中，而 59 种推定的γ乳头瘤病毒类型则被分为 21 种未识别的推定物种。这些数据强调了需要在鉴定更多乳头瘤病毒科的分类群方面取得进展，以阐明这些病毒的多样性、进化和医学意义。
