Institute of Biochemistry, ETH Zurich, Zurich, Switzerland.
Physiology (Bethesda). 2013 Sep;28(5):298-309. doi: 10.1152/physiol.00005.2013.
Although nutrient availability is a major driver of cell growth, and continuous adaptation to nutrient supply is critical for the development and survival of all organisms, the molecular mechanisms of nutrient sensing are only beginning to emerge. Here, we highlight recent advances in the field of nutrient sensing and discuss arising principles governing how metabolism might regulate growth-promoting pathways. In addition, we discuss signaling functions of metabolic enzymes not directly related to their metabolic activity.
尽管营养物质的可获得性是细胞生长的主要驱动因素，并且持续适应营养供应对于所有生物的发育和生存都是至关重要的，但营养感知的分子机制才刚刚开始出现。在这里，我们重点介绍营养感知领域的最新进展，并讨论代谢如何调节促进生长的途径的基本原理。此外，我们还讨论了代谢酶与代谢活性不直接相关的信号转导功能。
