Estève M, Veillette Y, Ecoffey C, Orhant E E
Département d'Anesthésie-Réanimation, Hôpital de Bicêtre, Université Paris-Sud, Le Kremlin-Bicêtre.
Ann Fr Anesth Reanim. 1990;9(4):322-5. doi: 10.1016/s0750-7658(05)80242-4.
Ten ASA Class 1 and 2 patients, aged from 16 to 56 years (mean +/- SD: 37 +/- 17 years), scheduled for knee surgery were studied. At the end of the surgical procedure under general anesthesia, an epidural catheter was inserted in the femoral space. After X-ray opacification, a bolus of 2.5 mg.kg-1 of 0.5% bupivacaine with epinephrine was injected. A maintenance infusion was performed during 48 hours with 0.25 mg.kg-1.h-1 of 0.125% bupivacaine without epinephrine. Pain score recorded with an visual analogue scale was 5.0 +/- 1.9 before femoral block. Pain score decreased significantly from 6 to 48 hours. Plasma bupivacaine levels at 24, 36 and 48 hours were significantly higher than the levels obtained at 30 min, 1, 6 and 12 hours. Mean plasma bupivacaine level at steady state was 1.78 +/- 0.59 micrograms.ml-1. Clearance of bupivacaine was 2.59 +/- 0.91 ml.min-1.kg-1. No neurologic complications have been recorded.
对10例年龄在16至56岁（平均±标准差：37±17岁）、计划进行膝关节手术的ASA 1级和2级患者进行了研究。在全身麻醉下手术结束时，在股间隙插入硬膜外导管。经X线显影后，注射一剂2.5mg.kg-1的含肾上腺素的0.5%布比卡因。在48小时内以0.125%不含肾上腺素的布比卡因0.25mg.kg-1.h-1进行维持输注。在股神经阻滞前，用视觉模拟量表记录的疼痛评分为5.0±1.9。疼痛评分在6至48小时内显著降低。24、36和48小时时的血浆布比卡因水平显著高于30分钟、1、6和12小时时的水平。稳态时的平均血浆布比卡因水平为1.78±0.59微克.ml-1。布比卡因的清除率为2.59±0.91ml.min-1.kg-1。未记录到神经并发症。
