磁共振成像增加了大鼠血脑屏障对钆喷酸葡胺（153-钆二乙三胺五乙酸）的通透性。

Magnetic resonance imaging increases the blood-brain barrier permeability to 153-gadolinium diethylenetriaminepentaacetic acid in rats.

作者信息

Prato F S, Frappier J R, Shivers R R, Kavaliers M, Zabel P, Drost D, Lee T Y

机构信息

Department of Nuclear Medicine, St. Joseph's Health Centre, London, Ont., Canada.

出版信息

Brain Res. 1990 Jul 23;523(2):301-4. doi: 10.1016/0006-8993(90)91502-8.

DOI:10.1016/0006-8993(90)91502-8

PMID:2400915

Abstract

In a qualitative electron microscopy study we initially reported that exposure of rats to a standard clinical magnetic resonance imaging (MRI) procedure temporarily increased the blood-brain barrier (BBB) permeability to horseradish peroxidase. In this study, we quantitatively support our initial finding. Rats were injected intracardially with radio-labelled diethylenetriaminepentaacetic acid [( 153Gd]DTPA) in the middle of two sequential 23.2 min MRI exposures. Exposed rats (n = 21) showed significantly greater (29%, P = 0.006) retention of [153 Gd]DTPA than sham-exposed rats (n = 22) 1 h after the end of the last 23.2 min exposure. These findings suggest that magnetic fields may alter BBB permeability.

摘要

在一项定性电子显微镜研究中，我们最初报告称，将大鼠暴露于标准临床磁共振成像（MRI）程序下会使血脑屏障（BBB）对辣根过氧化物酶的通透性暂时增加。在本研究中，我们对最初的发现进行了定量支持。在连续两次23.2分钟的MRI暴露过程中，于中间阶段给大鼠进行心内注射放射性标记的二乙三胺五乙酸[（153Gd）DTPA]。在最后一次23.2分钟暴露结束1小时后，暴露组大鼠（n = 21）对[153Gd]DTPA的保留量比假暴露组大鼠（n = 22）显著更高（29%，P = 0.006）。这些发现表明磁场可能会改变血脑屏障的通透性。