目前关于幽门螺杆菌根除对胃癌预防作用的证据。
Current evidence of effects of Helicobacter pylori eradication on prevention of gastric cancer.
机构信息
Center for Gastric Cancer, National Cancer Center, Goyang, Korea.
出版信息
Korean J Intern Med. 2013 Sep;28(5):525-37. doi: 10.3904/kjim.2013.28.5.525. Epub 2013 Aug 14.
Abstract
Gastric cancer is the second most common cause of cancer death worldwide and is usually detected at a late stage, except in Korea and Japan where early screening is in effect. Results from animal and epidemiological studies suggest that Helicobacter pylori infection, and subsequent gastritis, promote development of gastric cancer in the infected mucosa. Relatively effective treatment regimens are available to treat H. pylori infection, and in general, mass eradication of the organism is not currently recommended as a gastric cancer prevention strategy. However, regional guidelines vary regarding the indications and recommendations for H. pylori treatment for gastric cancer prevention. In this review, we discuss the results from intervention studies, provide insight regarding current guideline recommendations, and discuss future study directions.
摘要
胃癌是全球第二大常见癌症死因，通常在晚期才被发现，但在韩国和日本，早期筛查已得到实施。动物和流行病学研究的结果表明，幽门螺杆菌感染及其随后的胃炎会促进感染黏膜中胃癌的发展。目前已有相对有效的治疗方案可用于治疗 H. pylori 感染，通常不建议大规模根除该病原体作为胃癌预防策略。然而，针对胃癌预防的 H. pylori 治疗的适应证和推荐意见，各地区指南存在差异。在这篇综述中，我们讨论了干预研究的结果，提供了关于当前指南建议的见解，并讨论了未来的研究方向。
相似文献
1
Current evidence of effects of Helicobacter pylori eradication on prevention of gastric cancer.目前关于幽门螺杆菌根除对胃癌预防作用的证据。
Korean J Intern Med. 2013 Sep;28(5):525-37. doi: 10.3904/kjim.2013.28.5.525. Epub 2013 Aug 14.
2
Future candidates for indications of Helicobacter pylori eradication: do the indications need to be revised?未来的幽门螺杆菌根除适应证候选人：适应证需要修订吗？
J Gastroenterol Hepatol. 2012 Feb;27(2):200-11. doi: 10.1111/j.1440-1746.2011.06961.x.
3
Strategy for the treatment of Helicobacter pylori infection.幽门螺杆菌感染的治疗策略。
Curr Pharm Des. 2014;20(28):4489-500. doi: 10.2174/13816128113196660731.
4
Management of Helicobacter pylori infection after gastric surgery.胃手术后幽门螺杆菌感染的管理。
World J Gastroenterol. 2014 May 14;20(18):5274-82. doi: 10.3748/wjg.v20.i18.5274.
5
Eradication rate and histological changes after Helicobacter pylori eradication treatment in gastric cancer patients following subtotal gastrectomy.胃癌患者胃大部切除术后幽门螺杆菌根除治疗后的根除率及组织学变化。
World J Gastroenterol. 2015 Apr 7;21(13):3936-43. doi: 10.3748/wjg.v21.i13.3936.
6
Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report.幽门螺杆菌感染的管理——马斯特里赫特 V/佛罗伦萨共识报告。
Gut. 2017 Jan;66(1):6-30. doi: 10.1136/gutjnl-2016-312288. Epub 2016 Oct 5.
7
8
Screening and eradication of for gastric cancer prevention: the Taipei global consensus.胃癌预防的筛查和根除：台北全球共识。
Gut. 2020 Dec;69(12):2093-2112. doi: 10.1136/gutjnl-2020-322368. Epub 2020 Oct 1.
9
[Helicobacter pylori-associated diseases].[幽门螺杆菌相关疾病]
Gastroenterol Hepatol. 2015 Sep;38 Suppl 1:39-48. doi: 10.1016/S0210-5705(15)30018-2.
10
Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer.幽门螺杆菌根除对胃癌远端胃切除术后长期生存的影响。
Cancer Res Treat. 2016 Jul;48(3):1020-9. doi: 10.4143/crt.2015.264. Epub 2015 Nov 17.
引用本文的文献
1
Changes in Helicobacter pylori Status in Patients Who Underwent Partial Gastrectomy for Gastric Cancer Therapy.接受胃癌治疗的部分胃切除术患者幽门螺杆菌状态的变化
Korean J Helicobacter Up Gastrointest Res. 2025 Jun;25(2):191-194. doi: 10.7704/kjhugr.2025.0018. Epub 2025 Jun 4.
2
Anti-Helicobacter pylori Treatment in Patients With Gastric Cancer After Radical Gastrectomy.根治性胃切除术后胃癌患者的抗幽门螺杆菌治疗。
JAMA Netw Open. 2024 Mar 4;7(3):e243812. doi: 10.1001/jamanetworkopen.2024.3812.
3
Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study.远端胃切除患者中幽门螺杆菌和乳糜泻抗体阳性率更高：一项横断面回顾性研究
Cureus. 2023 Aug 5;15(8):e42976. doi: 10.7759/cureus.42976. eCollection 2023 Aug.
4
Detection of Microbial 16S rRNA Gene in the Serum of Patients With Gastric Cancer.胃癌患者血清中微生物16S rRNA基因的检测
Front Oncol. 2019 Jul 9;9:608. doi: 10.3389/fonc.2019.00608. eCollection 2019.
5
Endoscopic gastritis, serum pepsinogen assay, and Helicobacter pylori infection.内镜下胃炎、血清胃蛋白酶原检测及幽门螺杆菌感染
Korean J Intern Med. 2016 Sep;31(5):835-44. doi: 10.3904/kjim.2016.166. Epub 2016 Sep 1.
6
Association of helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: A ten-year follow-up of the ESTHER cohort study.幽门螺杆菌感染和慢性萎缩性胃炎与结肠癌、胰腺癌和胃癌风险的关联：ESTHER队列研究的十年随访
Oncotarget. 2016 Mar 29;7(13):17182-93. doi: 10.18632/oncotarget.7946.
7
Diagnosis and management of gastric dysplasia.胃发育异常的诊断与管理
Korean J Intern Med. 2016 Mar;31(2):201-9. doi: 10.3904/kjim.2016.021. Epub 2016 Feb 26.
8
Effect of Helicobacter pylori Eradication on Long-Term Survival after Distal Gastrectomy for Gastric Cancer.幽门螺杆菌根除对胃癌远端胃切除术后长期生存的影响。
Cancer Res Treat. 2016 Jul;48(3):1020-9. doi: 10.4143/crt.2015.264. Epub 2015 Nov 17.
9
Gastric cancer: prevention, screening and early diagnosis.胃癌：预防、筛查与早期诊断
World J Gastroenterol. 2014 Oct 14;20(38):13842-62. doi: 10.3748/wjg.v20.i38.13842.
10
IL-17A G197A and C1249T polymorphisms in gastric carcinogenesis.白细胞介素-17A基因G197A和C1249T多态性与胃癌发生
Tumour Biol. 2014 Oct;35(10):9977-85. doi: 10.1007/s13277-014-2288-z. Epub 2014 Jul 10.
本文引用的文献
1
The association between Helicobacter pylori status and incidence of metachronous gastric cancer after endoscopic resection of early gastric cancer.早期胃癌内镜切除术后幽门螺杆菌状态与异时性胃癌发生率之间的关联。
Helicobacter. 2014 Jun;19(3):194-201. doi: 10.1111/hel.12116. Epub 2014 Mar 10.
2
[Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition].《2013年修订版韩国幽门螺杆菌感染诊断和治疗指南》
Korean J Gastroenterol. 2013 Jul;62(1):3-26. doi: 10.4166/kjg.2013.62.1.3.
3
Randomised clinical trial: the effects of Helicobacter pylori eradication on glandular atrophy and intestinal metaplasia after subtotal gastrectomy for gastric cancer.随机临床试验：胃癌胃大部切除术后幽门螺杆菌根除对腺体萎缩和肠上皮化生的影响。
Aliment Pharmacol Ther. 2013 Sep;38(5):477-89. doi: 10.1111/apt.12402. Epub 2013 Jul 3.
4
Cost-effectiveness outcomes of the national gastric cancer screening program in South Korea.韩国国家胃癌筛查项目的成本效益结果。
Asian Pac J Cancer Prev. 2013;14(4):2533-40. doi: 10.7314/apjcp.2013.14.5.2533.
5
How long will it take to reduce gastric cancer incidence by eradicating Helicobacter pylori infection?根除幽门螺杆菌感染能降低胃癌发病率需要多长时间？
Cancer Prev Res (Phila). 2013 Jul;6(7):695-700. doi: 10.1158/1940-6207.CAPR-12-0428. Epub 2013 May 16.
6
Protective role of Helicobacter pylori infection in prognosis of gastric cancer: evidence from 2,454 patients with gastric cancer.幽门螺杆菌感染对胃癌预后的保护作用：来自 2454 例胃癌患者的证据。
PLoS One. 2013 May 7;8(5):e62440. doi: 10.1371/journal.pone.0062440. Print 2013.
7
Association of Helicobacter pylori seropositivity with all-cause mortality: fact or fiction?
Gut. 2013 Sep;62(9):1385-6. doi: 10.1136/gutjnl-2013-304991. Epub 2013 Apr 30.
8
Association between Helicobacter pylori and mortality in the NHANES III study.幽门螺杆菌与 NHANES III 研究中死亡率的关系。
Gut. 2013 Sep;62(9):1262-9. doi: 10.1136/gutjnl-2012-303018. Epub 2013 Jan 8.
9
Fourth Chinese National Consensus Report on the management of Helicobacter pylori infection.《中国第四次幽门螺杆菌感染管理全国共识报告》
J Dig Dis. 2013 May;14(5):211-21. doi: 10.1111/1751-2980.12034.
10
A new approach for elimination of gastric cancer deaths in Japan.在日本消除胃癌死亡的新方法。
Int J Cancer. 2013 Mar 15;132(6):1272-6. doi: 10.1002/ijc.27965. Epub 2012 Dec 21.
Zotero 插件