伊朗类风湿关节炎患者队列中抗环瓜氨酸肽抗体和抗巨细胞病毒抗体的敏感性和特异性比较。
Comparison of sensitivity and specificity of anti-CCP and anti-MCV antibodies in an Iranian cohort of patients with rheumatoid arthritis.
作者信息
Yousefghahari Behnaz, Alhooei Saman, Soleimani-Amiri Mohammad Jafar, Guran Ardeshir
机构信息
Department of Rheumatology, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
出版信息
Caspian J Intern Med. 2013 Summer;4(3):702-6.
UNLABELLED
Background : Anti-CCP is a test commonly used for the diagnosis of rheumatoid arthritis. The aim of this study was to determine the diagnostic values of ACCP compared to anti-MCV in rheumatoid arthritis patients in north of Iran.
METHODS
The serum samples of 150 RA patients and 75 controls, with the mean age of 49.6+11.8 and 48.8+12 years respectively, were tested using the commercially available ELISA kits for ACCP and anti-MCV. Sensitivity, Specificity were determined and Roc curve were used for comparison between these two groups.
RESULTS
The sensitivity of ACCP versus anti-MCV was 85% and 81%, respectively. Specificity was 96% and 95%, respectively. In the RA patients, ACCP was positive in 127 (84.7%) and anti MCV in 121 (80.7%) cases. In the control group, these parameters were positive in 3 (4%) and 4 (5.3%) (p<0.0001 and p<0.0001, respectively). The correlation coefficient for ACCP and anti-MCV was calculated at 0.63 (p<0.001). The area under the curve for ACCP was 0.941±0.015 (p<0.001), anti-MCV was 0.902±0.02 (p<0.001). The measure of agreement (Kappa) for these variables was 0.81. In these patients, there was no correlation between DAS28 and the positivity of these tests.
CONCLUSION
It was concluded, compared to ACCP, anti-MCV has approximately the same accuracy for the diagnosis of rheumatoid arthritis and it does not have additional value.
未标注
背景：抗环瓜氨酸肽（anti-CCP）是常用于类风湿关节炎诊断的一项检测。本研究的目的是确定在伊朗北部类风湿关节炎患者中，与抗聚角蛋白微丝蛋白抗体（anti-MCV）相比，抗环瓜氨酸肽（ACCP）的诊断价值。
方法
使用市售的抗环瓜氨酸肽（ACCP）和抗聚角蛋白微丝蛋白抗体（anti-MCV）酶联免疫吸附测定试剂盒，对150例类风湿关节炎患者和75例对照者的血清样本进行检测，患者和对照者的平均年龄分别为49.6±11.8岁和48.8±12岁。确定敏感性、特异性，并使用Roc曲线对这两组进行比较。
结果
抗环瓜氨酸肽（ACCP）与抗聚角蛋白微丝蛋白抗体（anti-MCV）的敏感性分别为85%和81%。特异性分别为96%和95%。在类风湿关节炎患者中，127例（84.7%）抗环瓜氨酸肽（ACCP）呈阳性，121例（80.7%）抗聚角蛋白微丝蛋白抗体（anti-MCV）呈阳性。在对照组中，这些指标分别有3例（4%）和4例（5.3%）呈阳性（p均<0.0001）。抗环瓜氨酸肽（ACCP）与抗聚角蛋白微丝蛋白抗体（anti-MCV）的相关系数计算为0.63（p<0.001）。抗环瓜氨酸肽（ACCP）的曲线下面积为0.941±0.015（p<0.001），抗聚角蛋白微丝蛋白抗体（anti-MCV）的曲线下面积为0.902±0.02（p<0.001）。这些变量的一致性度量（Kappa）为0.81。在这些患者中，疾病活动评分28（DAS28）与这些检测的阳性结果之间无相关性。
结论
得出结论，与抗环瓜氨酸肽（ACCP）相比，抗聚角蛋白微丝蛋白抗体（anti-MCV）在类风湿关节炎诊断中的准确性大致相同，且不具有额外价值。
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