Ahmadi-Motamayel Fatemeh, Shahriari Shahriar, Goodarzi Mohammad Taghi, Moghimbeigi Abbas, Jazaeri Mina, Babaei Parisa
Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences Faculty of Dentistry, Hamadan, Iran.
Restor Dent Endod. 2013 Aug;38(3):141-5. doi: 10.5395/rde.2013.38.3.141. Epub 2013 Aug 23.
Assessment of dental pain severity is very challenging in dentistry. Previous studies have suggested that elevated salivary alpha amylase may contribute to increased physical stresses. There is a close association between salivary alpha amylase and plasma norepinephrine under stressful physical conditions. The aim of this study was to evaluate the relationship between pain severity and salivary alpha amylase levels in patients with symptomatic irreversible pulpitis.
Thirty-six patients (20 females and 16 males) with severe tooth pain due to symptomatic irreversible pulpitis were selected. The visual analogue scale (VAS) score was used to assess the pain severity in each patient. Unstimulated whole saliva was collected, and the level of alpha amylase activity was assessed by the spectrophotometric method. Statistical analysis was performed using SPSS 13.
The level of alpha amylase was significantly increased in the saliva in association with pain severity assessed by VAS. The salivary alpha amylase was also elevated with increased age and in males.
There was a significant correlation between the VAS pain scale and salivary alpha amylase level, which indicates this biomarker may be a good index for the objective assessment of pain intensity.
在牙科领域，评估牙齿疼痛的严重程度极具挑战性。先前的研究表明，唾液α淀粉酶升高可能会导致身体应激增加。在身体应激状态下，唾液α淀粉酶与血浆去甲肾上腺素之间存在密切关联。本研究的目的是评估有症状的不可逆性牙髓炎患者疼痛严重程度与唾液α淀粉酶水平之间的关系。
选取36例因有症状的不可逆性牙髓炎而出现严重牙痛的患者（20例女性，16例男性）。采用视觉模拟量表（VAS）评分评估每位患者的疼痛严重程度。收集非刺激性全唾液，采用分光光度法评估α淀粉酶活性水平。使用SPSS 13进行统计分析。
唾液中α淀粉酶水平随VAS评估的疼痛严重程度显著升高。唾液α淀粉酶水平也随年龄增长和男性性别而升高。
VAS疼痛量表与唾液α淀粉酶水平之间存在显著相关性，这表明该生物标志物可能是客观评估疼痛强度的良好指标。
