Illescas-Montes Rebeca, Costela-Ruiz Víctor J, Melguizo-Rodríguez Lucía, De Luna-Bertos Elvira, Ruiz Concepción, Ramos-Torrecillas Javier
Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, 18016, Granada, Spain.
Instituto Investigación Biosanitaria, ibs.Granada, University of Granada, 18016 Granada, Spain.
Diagnostics (Basel). 2021 Jan 3;11(1):63. doi: 10.3390/diagnostics11010063.
Fibromyalgia (FM) is a highly prevalent syndrome that impairs the quality of life of the patients; however, its diagnosis is complex and mainly centered on pain symptoms. The study of salivary biomarkers has proven highly useful for the diagnosis and prognosis of numerous diseases. The objective of this review was to gather published data on the utilization of salivary biomarkers to facilitate and complement the diagnosis of FM. Salivary biomarkers used in FM diagnosis include cortisol; calgranulin; and the enzymes α-amylase, transaldolase, and phosphoglycerate mutase. Increased serum levels of C-reactive protein, cytokines interleukin 1-β, interleukin 6, interleukin 8, interleukin 10, interleukin 17, tumor necrosis factor α, and various chemokines may serve as salivary biomarkers, given observations of their increased serum levels in patients with FM. Further research is warranted to study in depth the role and performance of biomarkers currently used in FM diagnosis/prognosis and to identify novel salivary biomarkers for this disease.
纤维肌痛（FM）是一种非常普遍的综合征，会损害患者的生活质量；然而，其诊断较为复杂，主要集中在疼痛症状上。唾液生物标志物的研究已被证明对多种疾病的诊断和预后非常有用。本综述的目的是收集已发表的关于唾液生物标志物用于促进和补充FM诊断的数据。用于FM诊断的唾液生物标志物包括皮质醇、钙粒蛋白以及α-淀粉酶、转醛醇酶和磷酸甘油酸变位酶等酶。鉴于在FM患者中观察到血清中C反应蛋白、细胞因子白细胞介素1-β、白细胞介素6、白细胞介素8、白细胞介素10、白细胞介素17、肿瘤坏死因子α以及各种趋化因子水平升高，这些物质的血清水平升高可能作为唾液生物标志物。有必要进一步深入研究目前用于FM诊断/预后的生物标志物的作用和性能，并为该疾病鉴定新的唾液生物标志物。
