Yuan Qian, Jiang Hong-Tao, Su Ying-Lan, Yang Jiang-Gen
Department of Urology, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, China.
Zhonghua Nan Ke Xue. 2013 Aug;19(8):719-21.
To evaluate the correlation of neutral alpha-glucosidase in seminal plasma with the location of epididymal obstruction in azoospermia men.
We detected neutral alpha-glucosidase activity in the seminal plasma of 59 men with obstructive azoospermia followed by determining the location of epididymal obstruction by scrotal exploratory surgery. Then we analyzed the correlation between neutral alpha-glucosidase and the location of epididymal obstructive azoospermia.
Among the total number of patients, there were 25 cases of bilateral cauda epididymal obstruction, 15 bilateral corpus, 12 bilateral caput, 4 unilateral caput-opposite cauda, and 3 unilateral corpus-opposite cauda. The neutral alpha-glucosidase levels in the seminal plasma of bilateral cauda, corpus and capus epididymal obstructions were (4.1 +/- 1.9), (13.8 +/- 4.4) and (46.8 +/- 19.3) mU per ejaculate, respectively, with statistically significant differences among the three groups (P < 0.05).
Neutral alpha-glucosidase activity is significantly correlated with the location of epididymal obstruction in azoospermia men, which helps to locate epididymal obstruction, evaluate surgical prognosis and reduce the time of scrotal exploratory surgery.
评估无精子症男性精液中中性α-葡萄糖苷酶与附睾梗阻部位的相关性。
检测59例梗阻性无精子症男性精液中的中性α-葡萄糖苷酶活性，随后通过阴囊探查手术确定附睾梗阻部位。然后分析中性α-葡萄糖苷酶与附睾梗阻性无精子症部位之间的相关性。
在全部患者中，双侧附睾尾部梗阻25例，双侧附睾体部梗阻15例，双侧附睾头部梗阻12例，单侧附睾头部-对侧附睾尾部梗阻4例，单侧附睾体部-对侧附睾尾部梗阻3例。双侧附睾尾部、体部和头部梗阻患者精液中中性α-葡萄糖苷酶水平分别为每射精一次（4.1±1.9）、（13.8±4.4）和（46.8±19.3）mU，三组间差异有统计学意义（P<0.05）。
中性α-葡萄糖苷酶活性与无精子症男性附睾梗阻部位显著相关，有助于定位附睾梗阻、评估手术预后并减少阴囊探查手术时间。
