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本文引用的文献

1
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile.B 细胞通过调节 T 细胞功能和炎症细胞因子谱促进肥胖和 2 型糖尿病中的炎症反应。
Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5133-8. doi: 10.1073/pnas.1215840110. Epub 2013 Mar 11.
2
Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice.肥胖 IFN-γ 基因敲除小鼠的全身炎症与胰岛素敏感性
Metabolism. 2012 Aug;61(8):1152-61. doi: 10.1016/j.metabol.2012.01.018. Epub 2012 Mar 3.
3
The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes.自然杀伤细胞与未极化或极化的巨噬细胞相互作用会产生不同的功能结果。
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21659-64. doi: 10.1073/pnas.1007654108. Epub 2010 Nov 30.
4
Bariatric surgery reverses natural killer (NK) cell activity and NK-related cytokine synthesis impairment induced by morbid obesity.减重手术可逆转病态肥胖引起的自然杀伤 (NK) 细胞活性和与 NK 相关的细胞因子合成障碍。
Obes Surg. 2011 Jan;21(1):112-8. doi: 10.1007/s11695-010-0250-8.
5
Imbalance of NKp44(+)NKp46(-) and NKp44(-)NKp46(+) natural killer cells in the intestinal mucosa of patients with Crohn's disease.克罗恩病患者肠道黏膜中 NKp44(+)NKp46(-)和 NKp44(-)NKp46(+)自然杀伤细胞的失衡。
Gastroenterology. 2010 Sep;139(3):882-92, 892.e1-3. doi: 10.1053/j.gastro.2010.05.040. Epub 2010 Jun 1.
6
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.CD8 + 效应T细胞在肥胖症中促进巨噬细胞募集和脂肪组织炎症。
Nat Med. 2009 Aug;15(8):914-20. doi: 10.1038/nm.1964. Epub 2009 Jul 26.
7
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.瘦而非肥胖的个体中，脂肪富含一群独特的调节性T细胞，这些细胞会影响代谢参数。
Nat Med. 2009 Aug;15(8):930-9. doi: 10.1038/nm.2002. Epub 2009 Jul 26.
8
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue.脂肪组织中 NK 细胞和 IFN-γ在炎症反应中的作用及储存部位特异性炎症介质差异。
Int J Obes (Lond). 2009 Sep;33(9):978-90. doi: 10.1038/ijo.2009.133. Epub 2009 Jun 30.
9
Altered phenotype of NK cells from obese rats can be normalized by transfer into lean animals.肥胖大鼠 NK 细胞表型的改变可以通过转移到瘦小动物中得到纠正。
Obesity (Silver Spring). 2009 Oct;17(10):1848-55. doi: 10.1038/oby.2009.140. Epub 2009 May 14.
10
Are natural killer cells protecting the metabolically healthy obese patient?自然杀伤细胞是否在保护代谢健康的肥胖患者？
Obesity (Silver Spring). 2009 Mar;17(3):601-5. doi: 10.1038/oby.2008.565. Epub 2008 Dec 18.

脂肪组织自然杀伤细胞在人类肥胖中表现出活化表型。

Adipose tissue NK cells manifest an activated phenotype in human obesity.

机构信息

Department of Surgery, Oregon Health & Science University, Portland, OR, USA.

出版信息

Metabolism. 2013 Nov;62(11):1557-61. doi: 10.1016/j.metabol.2013.07.011. Epub 2013 Sep 5.

DOI:10.1016/j.metabol.2013.07.011
PMID:24012153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3809342/
Abstract

OBJECTIVE

Adipose tissue inflammation is a cause of obesity-related metabolic disease. Natural killer (NK) cells are an understudied cell type in the context of obesity. The goal of this study was to determine the phenotype of human adipose tissue NK cells.

METHODS

We used flow cytometry phenotyping to study adipose tissue and peripheral blood NK cells from obese and lean humans.

RESULTS

Human adipose tissue NK cells, relative to peripheral blood NK cells, express increased levels of activation markers. Adipose tissue NK cells also demonstrate an activated phenotype in obese relative to lean subjects, with increased expression of the activating receptor NKG2D.

CONCLUSIONS

These data are the first detailed phenotypic characterization of human adipose tissue NK cells, and suggest a role for NK cells in adipose tissue inflammation in obesity.

摘要

目的

脂肪组织炎症是肥胖相关代谢疾病的一个原因。自然杀伤 (NK) 细胞在肥胖背景下是一种研究不足的细胞类型。本研究的目的是确定人脂肪组织 NK 细胞的表型。

方法

我们使用流式细胞术表型分析来研究肥胖和瘦人脂肪组织和外周血 NK 细胞。

结果

与外周血 NK 细胞相比，人脂肪组织 NK 细胞表达高水平的激活标志物。与瘦人相比，肥胖人的脂肪组织 NK 细胞也表现出激活表型，其激活受体 NKG2D 的表达增加。

结论

这些数据首次详细描述了人脂肪组织 NK 细胞的表型特征，并提示 NK 细胞在肥胖脂肪组织炎症中可能发挥作用。