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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

de la Cruz J, Burón I, Roncero I

Departamento de Bioquïmica, Facultad de Medicina, Universidad Complutense, Madrid, España.

Int J Biochem. 1990;22(7):729-35. doi: 10.1016/0020-711x(90)90008-q.

Mitochondria show morphological changes on aging: the volume density decreases and the total surface area or volume increase. 2. Biochemical studies indicated a decrease in the rate of oxygen consumption and ATP levels for increasing age. Measurements of calcium transport across the mitochondrial membrane revealed a decrease in accumulated calcium and an alteration in the uptake kinetics of the ion in older animals. 3. Theophylline and calcitonin action were also studied. In both age groups (young and old) theophylline shows an inhibitory effect on all the parameters studied (both morphological and biochemical). 4. Calcitonin showed no effect on morphological and respiratory parameters, although it increased calcium uptake into the mitochondrion to a lesser extent in the 24 month old animals.

线粒体在衰老过程中呈现形态学变化：体积密度降低，总表面积或体积增加。2. 生化研究表明，随着年龄增长，氧气消耗速率和ATP水平降低。对线粒体膜钙转运的测量显示，老年动物中积累的钙减少，离子摄取动力学发生改变。3. 还研究了茶碱和降钙素的作用。在两个年龄组（年轻和年老）中，茶碱对所有研究参数（形态学和生化参数）均显示出抑制作用。4. 降钙素对形态学和呼吸参数没有影响，尽管它在24月龄动物中使线粒体对钙的摄取略有增加。

de la Cruz J, Burón I, Roncero I

Departamento de Bioquïmica, Facultad de Medicina, Universidad Complutense, Madrid, España.

Int J Biochem. 1990;22(7):729-35. doi: 10.1016/0020-711x(90)90008-q.

Mitochondria show morphological changes on aging: the volume density decreases and the total surface area or volume increase. 2. Biochemical studies indicated a decrease in the rate of oxygen consumption and ATP levels for increasing age. Measurements of calcium transport across the mitochondrial membrane revealed a decrease in accumulated calcium and an alteration in the uptake kinetics of the ion in older animals. 3. Theophylline and calcitonin action were also studied. In both age groups (young and old) theophylline shows an inhibitory effect on all the parameters studied (both morphological and biochemical). 4. Calcitonin showed no effect on morphological and respiratory parameters, although it increased calcium uptake into the mitochondrion to a lesser extent in the 24 month old animals.

线粒体在衰老过程中呈现形态学变化：体积密度降低，总表面积或体积增加。2. 生化研究表明，随着年龄增长，氧气消耗速率和ATP水平降低。对线粒体膜钙转运的测量显示，老年动物中积累的钙减少，离子摄取动力学发生改变。3. 还研究了茶碱和降钙素的作用。在两个年龄组（年轻和年老）中，茶碱对所有研究参数（形态学和生化参数）均显示出抑制作用。4. 降钙素对形态学和呼吸参数没有影响，尽管它在24月龄动物中使线粒体对钙的摄取略有增加。