相变脂多糖结构增强流感嗜血杆菌的侵袭能力。
Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae.
作者信息
Weiser J N, Williams A, Moxon E R
机构信息
Department of Paediatrics, University of Oxford, John Radcliffe Hospital, United Kingdom.
出版信息
Infect Immun. 1990 Oct;58(10):3455-7. doi: 10.1128/iai.58.10.3455-3457.1990.
Abstract
Genes necessary for the expression and phase variation of lipopolysaccharide epitopes of a virulent Haemophilus influenzae type b isolate (RM.7004) are contained within two chromosomal loci designated lic-1 and lic-2. Mutations were introduced into both lic-1 and lic-2, and the virulence of the double mutant was compared with that of the wild type in infant rats. These mutations in RM.7004 resulted in a significantly reduced incidence of bacteremia following intranasal inoculation, although nasopharyngeal colonization was similar for the mutant and wild-type strains. In contrast, no differences in bacteremia were observed when the mutant and wild-type strains were inoculated intraperitoneally.
摘要
一株强毒性的b型流感嗜血杆菌分离株（RM.7004）脂多糖表位表达和相变所必需的基因包含在两个染色体位点，分别命名为lic-1和lic-2。在lic-1和lic-2中都引入了突变，并在幼鼠中将双突变体的毒力与野生型进行了比较。RM.7004中的这些突变导致鼻内接种后菌血症的发生率显著降低，尽管突变株和野生型菌株在鼻咽部的定植情况相似。相比之下，当突变株和野生型菌株进行腹腔内接种时，未观察到菌血症有差异。
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