Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH.
Am Heart J. 2013 Sep;166(3):392-400. doi: 10.1016/j.ahj.2013.05.021. Epub 2013 Jul 3.
The goal of this systematic review was to assess the current understanding of the effects of exercise intervention on high-density lipoprotein (HDL) cholesterol (HDL-C) and changes in HDL function as well as modification of these effects by genomic factors. The reviewed studies demonstrate that exercise has modest effects on HDL-C with limited data suggesting an effect on HDL function. Genetic polymorphisms in proteins associated with HDL metabolism play a role in modifying the HDL-C response to exercise and possibly its function. Exercise as an intervention for patients at risk for cardiovascular events can lead to small improvements in HDL-C and potential changes in HDL function. There is an important modifier effect of genetics in determining these changes.
本系统评价的目的是评估运动干预对高密度脂蛋白胆固醇（HDL-C）的影响，以及对 HDL 功能的变化，以及基因组因素对这些影响的修正。综述研究表明，运动对 HDL-C 有适度的影响，数据有限，提示对 HDL 功能有影响。与 HDL 代谢相关的蛋白质的遗传多态性在改变运动对 HDL-C 的反应及其功能方面起着重要作用。运动作为心血管事件高危患者的干预措施，可以使 HDL-C 略有改善，并可能改变 HDL 功能。遗传在决定这些变化方面有重要的修饰作用。
