年轻乳腺癌幸存者的治疗选择和生活质量：短期随访。
Therapy choices and quality of life in young breast cancer survivors: a short-term follow-up.
机构信息
Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
出版信息
Am J Surg. 2013 Nov;206(5):625-31. doi: 10.1016/j.amjsurg.2013.08.003. Epub 2013 Sep 6.
Abstract
BACKGROUND
Premenopausal women represent approximately 35% of new breast cancer diagnoses. Diagnosis and treatment may lead to substantial disruption in quality of life (QOL).
METHODS
Premenopausal patients (aged 18 to 50 years) treated for nonmetastatic breast cancer completed a mailed questionnaire. Multiple self-reported QOL measures and clinical data were collected. Cluster analysis and Cronbach's α were used to validate the survey. Analysis of variance was performed for specific interventions. Lower interference scores conveyed higher QOL.
RESULTS
The response rate was 49.8%. Cronbach's α was 0.96. Immediate contralateral prophylactic mastectomy (CPM) carried the highest interference (mean, 3.3148) with sexuality compared with no CPM (mean, 2.85) or delayed CPM (P = .03). Breast conservation had the least interference with appearance (P < .01) and work and finances (P = .02).
CONCLUSIONS
Therapeutic mastectomy and CPM with or without reconstruction may adversely affect QOL. These findings suggest that the choice and timing of interventions may significantly affect patient satisfaction.
摘要
背景
绝经前女性约占新发乳腺癌诊断的 35%。诊断和治疗可能会导致生活质量（QOL）的严重下降。
方法
接受非转移性乳腺癌治疗的绝经前患者（年龄 18 至 50 岁）完成了邮寄问卷。收集了多种自我报告的 QOL 测量和临床数据。使用聚类分析和 Cronbach's α 对调查进行验证。对特定干预措施进行方差分析。较低的干扰评分表示较高的 QOL。
结果
回复率为 49.8%。Cronbach's α 为 0.96。即刻对侧预防性乳房切除术（CPM）对性的干扰最高（均值 3.3148），与无 CPM（均值 2.85）或延迟 CPM（P =.03）相比。保乳术对外观（P <.01）和工作和财务（P =.02）的干扰最小。
结论
乳房切除术和 CPM 术式（包括重建）可能会对 QOL 产生不利影响。这些发现表明，干预措施的选择和时机可能会显著影响患者的满意度。
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