部分伊朗海藻的抗疟和乙酰胆碱酯酶抑制活性筛选
Screening for antimalarial and acetylcholinesterase inhibitory activities of some Iranian seaweeds.
作者信息
Ghannadi A, Plubrukarn A, Zandi K, Sartavi K, Yegdaneh A
机构信息
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences and Isfahan Pharmaceutical Sciences Research centre, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
出版信息
Res Pharm Sci. 2013 Apr;8(2):113-8.
Alcoholic extracts of 8 different types of seaweeds from Iran's Persian Gulf were tested for their antimalarial and acetylcholinesterase enzyme (AChE) inhibitory activities for the first time. A modified Ellman and Ingkaninan method was used for measuring AChE inhibitory activity in which galanthamine was used as the reference. The antimalarial assay was performed using microculture radioisotope technique. Mefloquine and dihydroartemisinin were uased as the standards. The extract of Sargassum boveanum (Sargasseae family) showed the highest AChE inhibitory activity (IC50 equals to 1 mg ml(-1)) while Cystoseira indica (Cystoseiraceae family) exhibited the least activity (IC50 of 11 mg ml(-1)). The species from Rhodophyta (Gracilaria corticata and Gracilaria salicornia) also showed moderate activities (IC509.5, 8.7 mg ml(-1), respectively). All extracts were inactive in antimalarial assay.
首次对来自伊朗波斯湾的8种不同类型海藻的酒精提取物进行了抗疟疾和乙酰胆碱酯酶（AChE）抑制活性测试。采用改良的埃尔曼和英卡宁南方法测量AChE抑制活性，其中加兰他敏用作对照。使用微量培养放射性同位素技术进行抗疟疾试验。甲氟喹和双氢青蒿素用作标准品。波状马尾藻（马尾藻科）提取物显示出最高的AChE抑制活性（IC50等于1毫克/毫升），而印度囊藻（囊藻科）的活性最低（IC50为11毫克/毫升）。红藻门的物种（皮层江蓠和盐生江蓠）也显示出中等活性（IC50分别为9.5、8.7毫克/毫升）。所有提取物在抗疟疾试验中均无活性。
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