Jeena Kottarapat, Liju Vijayastelter B, Kuttan Ramadasan
Amala Cancer Research Centre, Amala Nagar, Thrissur--680 555, Kerala, India.
Indian J Physiol Pharmacol. 2013 Jan-Mar;57(1):51-62.
Chemical compositions of ginger oil as well as its antioxidant, anti-inflammatory and antinociceptive potential were evaluated in the present study. The main constituents as detected by GC/MS analysis was alpha-zingiberene which constituted 31% of the total area, ar-curcumene (15.4%) and a -sesquiphellandrene (14.02%). Ginger oil scavenged superoxide, DPPH, hydroxyl radicals and inhibited tissue lipid peroxidation in vitro. Intraperitoneal administration of ginger oil was found to inhibit phorbol-12-myristate-13-acetate induced superoxide radicals elicited by macrophages. Oral administration of ginger oil for one month, significantly increased superoxide dismutase, glutathione and glutathione reductase enzymes level (P < 0.001) in blood of mice and glutathione-S-transferase, glutathione peroxidase and superoxide dismutase enzymes in liver. Ginger oil produced significant reduction in acute inflammation produced by carrageenan and dextran and formalin induced chronic inflammation (P < 0.001). It also exhibited significant reduction in acetic acid induced writhing movements (P < 0.001). The present report revealed that ginger oil possesses antioxidant activity as well as significant anti-inflammatory and antinociceptive property.
本研究评估了姜油的化学成分及其抗氧化、抗炎和抗伤害感受的潜力。通过气相色谱/质谱分析检测到的主要成分是α-姜烯，其占总面积的31%，莪术烯（15.4%）和α-倍半水芹烯（14.02%）。姜油在体外清除超氧化物、二苯基苦味酰基自由基、羟基自由基并抑制组织脂质过氧化。发现腹腔注射姜油可抑制巨噬细胞诱导的佛波醇-12-肉豆蔻酸酯-13-乙酸酯诱导的超氧化物自由基。口服姜油一个月，可显著提高小鼠血液中超氧化物歧化酶、谷胱甘肽和谷胱甘肽还原酶的水平（P < 0.001）以及肝脏中谷胱甘肽-S-转移酶、谷胱甘肽过氧化物酶和超氧化物歧化酶的水平。姜油可显著减轻角叉菜胶和右旋糖酐引起的急性炎症以及福尔马林诱导的慢性炎症（P < 0.001）。它还能显著减少乙酸诱导的扭体运动（P < 0.001）。本报告显示，姜油具有抗氧化活性以及显著的抗炎和抗伤害感受特性。
