Division of Molecular Immunology, Cincinnati Children's Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Mol Metab. 2012 Aug 3;1(1-2):21-31. doi: 10.1016/j.molmet.2012.07.002. eCollection 2012.
The gut microbiome has been proposed to play a causal role in obesity. Here, we review the historical context for this hypothesis, highlight recent key findings, and critically discuss issues central to further progress in the field, including the central epistemological problem for the field: how to define causality in the relationship between microbiota and obesity phenotypes. Definition of such will be critical for the field to move forward.
肠道微生物群被认为在肥胖中起因果作用。在这里，我们回顾了这一假设的历史背景，强调了最近的关键发现，并批判性地讨论了该领域进一步发展的核心问题，包括该领域的中心认识论问题：如何定义微生物群与肥胖表型之间的关系中的因果关系。这种定义对于该领域的发展至关重要。
