Institute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania.
Front Cell Infect Microbiol. 2020 Dec 9;10:575559. doi: 10.3389/fcimb.2020.575559. eCollection 2020.
The current COVID-19 pandemic is a great challenge for worldwide researchers in the human microbiota area because the mechanisms and long-term effects of the infection at the GI level are not yet deeply understood. In the current review, scientific literature including original research articles, clinical studies, epidemiological reports, and review-type articles concerning human intestinal infection with SARS-CoV-2 and the possible consequences on the microbiota were reviewed. Moreover, the following aspects pertaining to COVID-19 have also been discussed: transmission, resistance in the human body, the impact of nutritional status in relation to the intestinal microbiota, and the impact of comorbid metabolic disorders such as inflammatory bowel disease (IBS), obesity, and type two diabetes (T2D). The articles investigated show that health, age, and nutritional status are associated with specific communities of bacterial species in the gut, which could influence the clinical course of COVID-19 infection. Fecal microbiota alterations were associated with fecal concentrations of SARS-CoV-2 and COVID-19 severity. Patients suffering from metabolic and gastrointestinal (GI) disorders are thought to be at a moderate-to-high risk of infection with SARS-CoV-2, indicating the direct implication of gut dysbiosis in COVID-19 severity. However, additional efforts are required to identify the initial GI symptoms of COVID-19 for possible early intervention.
当前的 COVID-19 大流行是全球人类微生物群领域研究人员面临的巨大挑战，因为目前还没有深入了解感染在胃肠道水平的机制和长期影响。在本综述中，我们回顾了有关人类肠道感染 SARS-CoV-2 以及对微生物组可能产生的影响的科学文献，包括原始研究文章、临床研究、流行病学报告和综述类型的文章。此外，还讨论了与 COVID-19 相关的以下方面：传播、人体的抵抗力、与肠道微生物群相关的营养状况的影响，以及炎症性肠病 (IBS)、肥胖症和 2 型糖尿病 (T2D) 等代谢紊乱合并症的影响。研究表明，健康状况、年龄和营养状况与肠道中特定的细菌物种群落有关，这可能会影响 COVID-19 感染的临床过程。粪便微生物群的改变与粪便中 SARS-CoV-2 的浓度和 COVID-19 的严重程度有关。患有代谢和胃肠道 (GI) 疾病的患者被认为有中度到高度感染 SARS-CoV-2 的风险，这表明肠道菌群失调与 COVID-19 的严重程度直接相关。然而，需要进一步努力确定 COVID-19 的最初胃肠道症状，以便可能进行早期干预。
