King D G, Grizzard W S, Sever R J, Espinoza L
Department of Ophthalmology, University of South Florida, Tampa.
Retina. 1990;10(2):97-101. doi: 10.1097/00006982-199004000-00001.
Elevated Factor VIII-von Willebrand factor antigen levels are associated with vascular endothelial injury in several disorders, including scleroderma, Raynaud's phenomenon, polymyalgia rheumatica, and temporal arteritis. Eight patients with serpiginous choroidopathy were evaluated with the use of quantitative immunoelectrophoresis for Factor VIII-von Willebrand factor antigen. The serpiginous choroidopathy patients had a mean Factor VIII-von Willebrand factor activity of 226 +/- 47.3%, whereas a disease-free, age- and sex-matched control group had a mean activity of 107 +/- 28%. These findings are statistically significant (P greater than 0.005) and suggest that in some patients, serpiginous choroidopathy represents an occlusive vascular phenomenon that involves the choroidal circulation.
在包括硬皮病、雷诺现象、风湿性多肌痛和颞动脉炎在内的多种疾病中，血管内皮损伤与因子VIII-血管性血友病因子抗原水平升高有关。我们采用定量免疫电泳法对8例匐行性脉络膜病变患者的因子VIII-血管性血友病因子抗原进行了评估。匐行性脉络膜病变患者的因子VIII-血管性血友病因子活性平均为226±47.3%，而年龄、性别匹配的无病对照组的平均活性为107±28%。这些发现具有统计学意义（P>0.005），表明在一些患者中，匐行性脉络膜病变代表一种涉及脉络膜循环的闭塞性血管现象。
