Giovannini A, Mariotti C, Ripa E, Scassellati-Sforzolini B
Clinica Oculistica, Università di Ancona, Nuovo Ospedale Regionale di Torrette, Italy.
Br J Ophthalmol. 1996 Jun;80(6):536-40. doi: 10.1136/bjo.80.6.536.
Analysis of the choroidal findings in patients affected by serpiginous choroidopathy (SC).
Thirteen patients (23 eyes; 11 males and two females; age range 50-68 years; mean age 59.1 years) affected by SC were examined with fluorescein angiography (FA) and indocyanine green angiography (ICGA). The follow up period was 7-33 months.
Using ICGA the disease could be divided into the following stages: (1) subclinical or choroidal stage (hypofluorescent lesions without FA evidence); (2) active stage (with ICGA and FA evidence); (3) subhealing stage (slight late hyperfluorescent lesions with ICGA, with no evidence on FA); (4) inactive or healed stage (hypofluorescent areas with ICGA and hyperfluorescent areas with FA).
Although FA showed a clear distinction between active and healed stages, ICGA allowed a greater subdivision of the disease. In particular, ICGA allowed: (1) better staging of SC, revealing choroidal alterations when there was no ophthalmoscopic or FA evidence; (2) better identification of the active lesions which appear to be larger at the choroidal level in comparison with the corresponding retinal lesions; and (3) revealed a persistence of choroidal activity even when the signs of retinal activity had disappeared. Thus, ICGA should be a particularly useful clinical and therapeutic monitoring tool of SC.
分析匐行性脉络膜病变（SC）患者的脉络膜表现。
对13例（23只眼；男性11例，女性2例；年龄范围50 - 68岁；平均年龄59.1岁）匐行性脉络膜病变患者进行荧光素血管造影（FA）和吲哚菁绿血管造影（ICGA）检查。随访期为7 - 33个月。
使用ICGA可将疾病分为以下阶段：（1）亚临床或脉络膜阶段（无FA证据的低荧光病变）；（2）活动期（有ICGA和FA证据）；（3）亚愈合期（ICGA显示轻微晚期高荧光病变，FA无证据）；（4）非活动或愈合期（ICGA显示低荧光区，FA显示高荧光区）。
虽然FA能清晰区分活动期和愈合期，但ICGA能对疾病进行更细致的分期。特别是，ICGA能够：（1）对匐行性脉络膜病变进行更好的分期，在无检眼镜或FA证据时揭示脉络膜改变；（2）更好地识别活动病变，与相应视网膜病变相比，脉络膜层面的活动病变似乎更大；（3）即使视网膜活动迹象消失，也能显示脉络膜活动的持续存在。因此，ICGA应是匐行性脉络膜病变一种特别有用的临床和治疗监测工具。
