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3 岁以下儿童手术后持续性睡眠呼吸暂停的预测因素。

Predictors of persistent sleep apnea after surgery in children younger than 3 years.

出版信息

JAMA Otolaryngol Head Neck Surg. 2013 Oct;139(10):1002-8. doi: 10.1001/jamaoto.2013.4686.

DOI:10.1001/jamaoto.2013.4686
PMID:24030757
Abstract

IMPORTANCE

Obstructive sleep apnea (OSA) is a common disorder in children and can lead to important sequelae. Predictors of persistent OSA after adenotonsillectomy (T&A) in younger children are not well studied.

OBJECTIVE

To evaluate residual OSA in a subgroup of children younger than 3 years after T&A and identify predictors of postoperative residual disease. DESIGN, SETTING, AND PARTICIPANTS Retrospective review of medical records at a tertiary academic children's hospital involving children younger than 3 years who had OSA documented by polysomnogram(PSG) and underwent T&A during the period October 1, 2002, through June 30, 2010. Some of these children had both preoperative and postoperative PSGs. MAIN OUTCOMES AND MEASURES Effect of T&A on sleep study parameters and predictors of persistent disease after surgery. RESULTS A total of 283 patients (mean [SD] age, 22 [7] months) underwent a preoperative PSG, with 70 of these patients having both a preoperative and postoperative PSG. In the group who had preoperative and postoperative PSGs, there were statistically significant improvements in mean (SD) apnea hypopnea index (AHI) (34.8 [40.7] to 5.7 [13.8]; P < .001), baseline oxygen saturation (96.6%[2.1%] to 97.2%[1.4%]; P = .05), minimum oxygen saturation (77.2%[11.4%] to 89.9%[6.8%]; P < .001), and sleep efficiency (84.7%[14.9%] to 88.7%[9.1%]; P = .02) after T&A. When AHI greater than 5 was used as the definition of OSA, 21% of the patients (15 of 70) had residual OSA. The most consistent predictor of residual OSA after T&A was the severity of preoperative OSA (P = .02). CONCLUSIONS AND RELEVANCE In a subgroup of children younger than 3 years with OSA, we found a high rate of residual OSA after T&A. Predictors of residual disease include severity of preoperative OSA as determined by PSG result. Postoperative PSGs might be indicated in these patients.

摘要

重要性

阻塞性睡眠呼吸暂停(OSA)是儿童中的一种常见疾病,可导致重要的后遗症。在接受腺样体扁桃体切除术(T&A)后的年幼儿童中,持续性 OSA 的预测因素尚未得到很好的研究。

目的

评估 T&A 后年龄小于 3 岁的儿童亚组中残留 OSA,并确定术后残留疾病的预测因素。

设计、地点和参与者:回顾性审查 2002 年 10 月 1 日至 2010 年 6 月 30 日期间,在一家三级学术儿童医院接受多导睡眠图(PSG)记录的 OSA 并接受 T&A 的年龄小于 3 岁的儿童的医疗记录。其中一些儿童进行了术前和术后 PSG。

主要结果和措施

T&A 对睡眠研究参数的影响以及手术后持续性疾病的预测因素。

结果

共 283 例患者(平均[标准差]年龄,22[7]个月)接受了术前 PSG,其中 70 例患者进行了术前和术后 PSG。在进行了术前和术后 PSG 的组中,平均(标准差)呼吸暂停低通气指数(AHI)(34.8[40.7]至 5.7[13.8];P<.001)、基线血氧饱和度(96.6%[2.1%]至 97.2%[1.4%];P=0.05)、最低血氧饱和度(77.2%[11.4%]至 89.9%[6.8%];P<.001)和睡眠效率(84.7%[14.9%]至 88.7%[9.1%];P=0.02)在 T&A 后均有统计学显著改善。当使用 AHI 大于 5 作为 OSA 的定义时,21%的患者(70 例中的 15 例)存在残留 OSA。T&A 后残留 OSA 的最一致预测因素是术前 OSA 的严重程度(P=0.02)。

结论和相关性

在患有 OSA 的年龄小于 3 岁的儿童亚组中,我们发现 T&A 后残留 OSA 的发生率很高。疾病残留的预测因素包括 PSG 结果确定的术前 OSA 严重程度。这些患者可能需要进行术后 PSG。

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