Mehrmohammadi Mohammad, Yoon Soon Joon, Yeager Douglas, Emelianov Stanislav Y
Department of Biomedical Engineering, University of Texas at Austin, Austin TX 78712, USA ; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55901, USA.
Curr Mol Imaging. 2013 Mar;2(1):89-105. doi: 10.2174/2211555211302010010.
Cancer is one of the leading causes of death in the world. Diagnosing a cancer at its early stages of development can decrease the mortality rate significantly and reduce healthcare costs. Over the past two decades, photoacoustic imaging has seen steady growth and has demonstrated notable capabilities to detect cancerous cells and stage cancer. Furthermore, photoacoustic imaging combined with ultrasound imaging and augmented with molecular targeted contrast agents is capable of imaging cancer at the cellular and molecular level, thus opening diverse opportunities to improve diagnosis of tumors, detect circulating tumor cells and identify metastatic lymph nodes. In this paper we introduce the principles of photoacoustic imaging, and review recent developments in photoacoustic imagingas an emerging imaging modality for cancer diagnosis and staging.
癌症是全球主要死因之一。在癌症发展的早期阶段进行诊断可显著降低死亡率并减少医疗成本。在过去二十年中，光声成像稳步发展，并已展现出检测癌细胞和对癌症进行分期的显著能力。此外，光声成像与超声成像相结合，并辅以分子靶向造影剂，能够在细胞和分子水平对癌症进行成像，从而为改善肿瘤诊断、检测循环肿瘤细胞和识别转移性淋巴结带来了诸多机会。在本文中，我们介绍光声成像的原理，并综述光声成像作为一种用于癌症诊断和分期的新兴成像模态的最新进展。
