长非编码 RNA 引领增强子生物学的新时代。
Long noncoding RNAs usher in a new era in the biology of enhancers.
机构信息
Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
出版信息
Cell. 2013 Sep 12;154(6):1190-3. doi: 10.1016/j.cell.2013.08.028.
Abstract
Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.
摘要
增强子相关的长链非编码 RNA 可远距离跨染色体作用，激活远端启动子的转录。在此，我们将介绍在理解长链非编码 RNA 表达的作用以及这些 RNA 通过与蛋白因子的结合和调节染色质结构参与增强子功能方面的最新进展。
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