Langholz B, Thomas D C
Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles 90033-9987.
Am J Epidemiol. 1990 Jan;131(1):169-76. doi: 10.1093/oxfordjournals.aje.a115471.
The recently developed case-cohort method of sampling from a cohort is compared with the nested case-control method. Corrected asymptotic relative efficiency results show that the case-cohort design for single "disease" outcomes offers less improvement for intervention trials for which there is no random censoring than originally suggested. Furthermore, simulation results indicate that if there is moderate random censoring or staggered entry, the case-cohort method can do substantially worse than the nested case-control method.
将最近开发的从队列中抽样的病例队列方法与巢式病例对照方法进行了比较。校正后的渐近相对效率结果表明，对于没有随机删失的干预试验，单一“疾病”结局的病例队列设计所带来的改善比最初设想的要小。此外，模拟结果表明，如果存在中度随机删失或交错入组，病例队列方法可能比巢式病例对照方法差得多。
