Department of Family Medicine, Cheng Hsin General Hospital, Taipei, Taiwan.
Department of Family Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
PLoS One. 2021 Nov 30;16(11):e0260550. doi: 10.1371/journal.pone.0260550. eCollection 2021.
To examine the association between metabolic syndrome (MetS) and successful aging among community-dwelling older adults.
Adults aged ≥ 65 years who participated in the senior health checkup program at National Taiwan University Hospital during 2011-2013 were recruited (N = 467 at baseline). The participants were followed after 4 years and 6 years. MetS was assessed at baseline. Successful aging was evaluated at baseline, 4-year follow-up, and 6-year follow-up. We adopted an extended definition of successful aging, which was defined as three major domains: physiological, psychological, and sociological and economic domains. Generalized linear mixed models were used to assess the association between MetS and successful aging adjusting for time (follow-up years), age, sex, years of education, alcohol consumption and MetS×time interaction term.
The mean age of the study population was 72.9 (SD 5.5) years. The absence of baseline MetS had a positive effect on the probability of successful aging over six years. The absences of abdominal obesity, hyperglycemia, reduced high-density lipoprotein cholesterol, and hypertension were associated with the physiological successful aging. The absence of hypertension was the most significant predictor of physiological successful aging [aOR (95% CI) = 2.76 (1.67-4.58), p<0.001]. Significant increased trend was found in the overall and physiological successful aging across MetS status (No MetS, pre MetS, MetS; Ptrend <0.001).
We found that MetS is a risk factor of successful aging among community-dwelling older adults. Public health policy should aim at avoidance of MetS in order to facilitate successful aging in older population.
探讨社区老年人代谢综合征（MetS）与成功老龄化的关系。
本研究纳入了 2011 年至 2013 年期间在国立台湾大学医院参加老年健康检查计划的年龄≥65 岁的成年人（基线时为 467 人）。在 4 年和 6 年后对参与者进行随访。基线时评估 MetS。在基线、4 年随访和 6 年随访时评估成功老龄化。我们采用了成功老龄化的扩展定义，将其定义为三个主要领域：生理、心理和社会学经济领域。采用广义线性混合模型，在调整时间（随访年）、年龄、性别、受教育年限、饮酒和 MetS×时间交互项的基础上，评估 MetS 与成功老龄化之间的关系。
研究人群的平均年龄为 72.9（5.5）岁。基线时无 MetS 对 6 年成功老龄化的概率有积极影响。无腹型肥胖、高血糖、低高密度脂蛋白胆固醇和高血压与生理成功老龄化有关。无高血压是生理成功老龄化的最显著预测因素[比值比（95%可信区间）=2.76（1.67-4.58），p<0.001]。随着 MetS 状态（无 MetS、前 MetS、MetS）的不同，整体和生理成功老龄化呈显著增加趋势（趋势 p<0.001）。
我们发现 MetS 是社区老年人成功老龄化的危险因素。公共卫生政策应旨在避免 MetS，以促进老年人口的成功老龄化。
