From the aInstitute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan; bDepartment of Pediatrics, Cardinal Tien Hospital Yonghe Branch, New Taipei, Taiwan; cDepartment of Preventive Medicine, Ewha Womans University School of Medicine, Seoul, Korea; dSchool and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, Taiwan; eDepartment of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan; fInstitute of Clinical Genomics, National Taiwan University College of Medicine, Taipei, Taiwan; gInstitute of Environmental Health, National Taiwan University College of Public Health, Taipei, Taiwan; hDepartment of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; iDepartment of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan; and jDepartment of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
Epidemiology. 2013 Nov;24(6):800-8. doi: 10.1097/EDE.0b013e3182a6dd46.
Epidemiologic data regarding the potential neurotoxicity of perfluorinated compounds (PFCs) are inconclusive. We investigated the associations between in utero exposure to perfluorooctanoic acid (PFOA) and perfluorooctyl sulfonate (PFOS) and early childhood neurodevelopment.
We recruited 239 mother-infant pairs in northern Taiwan from the Taiwan Birth Panel Study, which was established in 2004. We examined the association between PFCs in cord blood and children's neurodevelopment at 2 years of age, using the Comprehensive Developmental Inventory for Infants and Toddlers. This tool contains cognitive, language, motor, social, and self-help domains; test scores were further transformed into developmental quotients according to standardized norms. All multivariate regression models were adjusted for infant sex and gestational age, maternal education, family income, cord blood cotinine levels, postnatal environmental tobacco smoke exposure, and breastfeeding.
Prenatal PFOS concentrations in both untransformed and natural log (Ln)-transformed values were associated with adverse performance on the whole test and the domains related to development. A dose-response relationship was observed when PFOS levels were categorized into four groups. This association was most obvious in relation to the gross-motor subdomain. Across the PFOS interquartile range, the quotients of the gross-motor subdomain decreased by 3.7 points (95% confidence interval [CI] = -6.0 to -1.5), with an increasing odds ratio of poor performance (2.4; 95% CI = 1.3 to 4.2). In contrast, measures of association between PFOA concentrations and test scores were close to null.
Prenatal exposure to PFOS, but not PFOA, may affect children's development, especially gross-motor development at 2 years of age.
关于全氟化合物（PFCs）潜在神经毒性的流行病学数据尚无定论。我们研究了胎儿期暴露于全氟辛酸（PFOA）和全氟辛基磺酸（PFOS）与儿童早期神经发育之间的关系。
我们从 2004 年建立的台湾出生队列研究中招募了 239 对台湾北部的母婴对。我们使用婴儿和幼儿综合发育检查表评估了脐带血中 PFCs 与 2 岁儿童神经发育之间的关系。该工具包含认知、语言、运动、社会和自理领域；根据标准化规范，测试分数进一步转化为发育商数。所有多元回归模型均根据婴儿性别和胎龄、母亲教育程度、家庭收入、脐带血可替宁水平、产后环境烟草暴露和母乳喂养进行调整。
未转换和自然对数（Ln）转换值的产前 PFOS 浓度均与整个测试以及与发育相关的领域的不良表现有关。当 PFOS 水平分为四组时，观察到剂量-反应关系。这种关联在与粗大运动子域相关时最为明显。在整个 PFOS 四分位间距内，粗大运动子域的商数下降了 3.7 分（95%置信区间 [CI] = -6.0 至 -1.5），表现不佳的几率比增加 2.4 倍（95% CI = 1.3 至 4.2）。相比之下，PFOA 浓度与测试分数之间的关联指标接近零。
胎儿期暴露于 PFOS，而不是 PFOA，可能会影响儿童的发育，尤其是 2 岁时的粗大运动发育。
