产前全氟烷基物质暴露对新生儿和儿童生长的影响。
The impact of prenatal perfluoroalkyl substances exposure on neonatal and child growth.
机构信息
Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Pediatrics, National Taiwan University Hospital Yun-Lin Branch, Yunlin County, Taiwan; Department of Pediatrics, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan.
Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
出版信息
Sci Total Environ. 2017 Dec 31;607-608:669-675. doi: 10.1016/j.scitotenv.2017.06.273. Epub 2017 Jul 27.
BACKGROUND
Perfluoroalkyl substances (PFASs) are wildly distributed environmental pollutants. Laboratory mice exposed prenatally to PFASs develop smaller birth weight but are more likely to become obese in adulthood. The evidences in human studies are still inconclusive.
METHODS
The participants were 429 mother-infant pairs from Taiwan Birth Panel Study. These children were followed serially and growth data were collected through face to face interviews and records in Child Healthcare Handbooks until 108months of age. The age-specific z-scores for weight (WAZ), length/height (LAZ/HAZ) and BMI (BMIAZ) were calculated. PFASs in umbilical cord blood were analyzed by ultra-high-performance liquid chromatography/tandem mass spectrometry.
RESULTS
At birth, perfluorooctyl sulfonate (PFOS) levels were negatively associated with weight and height [per ln unit: adjusted β (95% confidence interval, CI)=-0.14 (-0.26, -0.01) for WAZ and -0.16 (-0.31, -0.02) for LAZ]. However, these adverse impacts diminished as children grow up. When stratified the analysis by gender, the effects of prenatal PFOS exposure were more obvious for girls especially during the time span of 6 to 12 and 12 to 24months of age [per ln unit: adjusted β (95% CI)=-0.25 (-0.47, -0.04) and -0.24 (-0.41, -0.04) for WAZ, respectively; per ln unit: adjusted β (95% CI)=-0.33 (-0.59, -0.08) and -0.25 (-0.45, -0.05) for BMIAZ, respectively]. Later in the period of 60 to 108months of age, positive association between prenatal PFOS exposure and girls' BMI was observed [per ln unit: adjusted β (95% CI)=0.34 (0.007, 0.68) for BMIAZ]. There was little evidence in these data for a consistent association of perfluorooctanoic acid (PFOA) with any of the indicators.
CONCLUSIONS
Our study had shown that higher prenatal PFOS exposure was associated with decreased fetal growth, but the effects were diminished as children grow up. Modest effect of gender specific manner was observed.
背景
全氟烷基物质（PFASs）是广泛分布的环境污染物。在实验室中，暴露于 PFASs 环境中的孕鼠所生的幼鼠出生体重较小，但成年后更易肥胖。但在人类研究中的证据尚不确定。
方法
本研究纳入了台湾出生队列研究中的 429 对母婴。这些儿童被连续随访，通过面对面访谈和儿童保健手册记录收集生长数据，直至 108 月龄。计算体重（WAZ）、长度/身高（LAZ/HAZ）和 BMI（BMIAZ）的年龄特异性 z 评分。通过超高效液相色谱/串联质谱法分析脐带血中的 PFASs。
结果
在出生时，全氟辛基磺酸（PFOS）水平与体重和身高呈负相关[每单位 ln：调整后的β（95%置信区间，CI）=-0.14（-0.26，-0.01），WAZ；-0.16（-0.31，-0.02），LAZ]。然而，随着儿童的成长，这些不利影响会逐渐减弱。当按性别分层分析时，产前 PFOS 暴露的影响在女孩中更为明显，尤其是在 6 至 12 个月和 12 至 24 个月的时间范围内[每单位 ln：调整后的β（95%CI）=-0.25（-0.47，-0.04）和-0.24（-0.41，-0.04），WAZ；-0.33（-0.59，-0.08）和-0.25（-0.45，-0.05），BMIAZ]。在 60 至 108 个月的后期，观察到产前 PFOS 暴露与女孩 BMI 之间呈正相关[每单位 ln：调整后的β（95%CI）=0.34（0.007，0.68），BMIAZ]。在这些数据中，几乎没有一致的证据表明全氟辛酸（PFOA）与任何指标相关。
结论
本研究表明，较高的产前 PFOS 暴露与胎儿生长受限有关，但随着儿童的成长，这种影响会减弱。观察到性别特异性的适度影响。
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