Jadoul M, Noel H, van Ypersele de Strihou C
Department of Nephrology, University of Louvain Medical School, Cliniques Universitaires St-Luc, Brussels, Belgium.
Am J Kidney Dis. 1990 Jan;15(1):86-8. doi: 10.1016/s0272-6386(12)80598-1.
The histological demonstration of beta 2-microglobulin (B2M) amyloidosis in a 75-year-old man treated exclusively by continuous ambulatory peritoneal dialysis (CAPD) for 87 months is reported. Amyloid deposits were detected in all joints from which synovial specimens were obtained at autopsy. It is of note that the patient had never undergone hemodialysis and had suffered only one episode of peritonitis. Both features are of interest, as the few reports of dialysis-related amyloidosis (DRA) in CAPD include patients who have been hemodialyzed and have suffered repeated episodes of peritonitis, both conditions being incriminated in the genesis of B2M amyloidosis. We conclude that DRA may develop in the absence of artificial membranes or frequent peritonitis episodes.
报道了一名75岁男性患者，仅接受持续非卧床腹膜透析（CAPD）治疗87个月，其β2微球蛋白（B2M）淀粉样变性的组织学表现。尸检时从所有获取滑膜标本的关节中均检测到淀粉样沉积物。值得注意的是，该患者从未接受过血液透析，仅发生过一次腹膜炎。这两个特征都很有意思，因为关于CAPD中与透析相关的淀粉样变性（DRA）的少数报道包括接受过血液透析且反复发生腹膜炎的患者，这两种情况都被认为与B2M淀粉样变性的发生有关。我们得出结论，在没有人工膜或频繁发生腹膜炎的情况下，也可能发生DRA。
