Neittaanmäki-Perttu Noora, Grönroos Mari, Tani Taneli, Pölönen Ilkka, Ranki Annamari, Saksela Olli, Snellman Erna
Department of Dermatology and Allergology, Päijät-Häme Social and Health Care Group, Lahti, Finland; Department of Mathematical Information Technology, University of Jyväskylä, Jyväskylä, Finland.
Lasers Surg Med. 2013 Sep;45(7):410-7. doi: 10.1002/lsm.22160.
Field cancerization denotes subclinical abnormalities in a tissue chronically exposed to UV radiation. These abnormalities can be found surrounding the clinically visible actinic keratoses.
The aim of this study was to test the feasibility of a hyperspectral imaging system in the detection of multiple clinical and subclinical AKs for early treatment of the affected areas.
Altogether 52 clinical AKs in 12 patients were included in this study. In six patients digital photos were taken of the naive AKs, and again after methylaminolevulinate(MAL)-fluorescence diagnosis which was used to teach HIS to find subclinical lesions. After 2-3 days when the MAL had vanished, the hyperspectral images were taken. Biopsies were taken from clinical AKs, healthy-looking skin and several suspected subclinical AKs. In the other six patients digital and hyperspectral images were taken of the naive AKs followed by one biopsy per patient.
HIS detected all clinically visible 52 AKs and numerous subclinical lesions. The histopathology of the 33 biopsied lesions were concordant with the HIS results showing either AK (n = 28) or photodamage (n = 5). Of the 28 histopathologically confirmed AKs, 16 were subclinical. A specific diffuse reflectance spectrum of an AK and healthy skin was defined.
The hyperspectral imaging system offers a new, non-invasive method for early detection of field cancerization. Lasers Surg. Med. 45:410-417, 2013. © 2013 Wiley Periodicals, Inc.
场癌化指的是长期暴露于紫外线辐射的组织中的亚临床异常。这些异常可在临床上可见的光化性角化病周围发现。
本研究的目的是测试高光谱成像系统在检测多个临床和亚临床光化性角化病以早期治疗受影响区域方面的可行性。
本研究共纳入了12例患者的52个临床光化性角化病。在6例患者中，对初发的光化性角化病拍摄数码照片，在使用氨基乙酰丙酸（MAL）进行荧光诊断以指导高光谱成像系统（HIS）发现亚临床病变后再次拍摄。在MAL消失2 - 3天后，拍摄高光谱图像。从临床光化性角化病、外观正常的皮肤以及几个疑似亚临床光化性角化病处取活检样本。在另外6例患者中，对初发的光化性角化病拍摄数码和高光谱图像，然后每位患者进行一次活检。
高光谱成像系统检测到了所有临床上可见的52个光化性角化病以及众多亚临床病变。33个活检病变的组织病理学结果与高光谱成像系统的结果一致，显示为光化性角化病（n = 28）或光损伤（n = 5）。在28个经组织病理学证实的光化性角化病中，16个为亚临床病变。定义了光化性角化病和健康皮肤的特定漫反射光谱。
高光谱成像系统为场癌化的早期检测提供了一种新的非侵入性方法。《激光外科与医学》45:410 - 417，2013年。© 2013威利期刊公司
