Division of Physical Biology and Bioimaging Center, Shanghai Synchrotron Radiation Facility (SSRF) Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China.
Adv Healthc Mater. 2014 Mar;3(3):354-9. doi: 10.1002/adhm.201300294. Epub 2013 Aug 26.
Both CdTe and CdTe/CdS/ZnS quantum dots induce similar levels of autophagy in PC12 and HEK293 cells, while the former exhibits higher toxicity. Low levels of cadmium ions are not sufficient to induce either autophagy or cytotoxicity by themselves. Interestingly, the combination of cadmium ions and CdTe/CdS/ZnS mimics the toxic effect of CdTe, suggesting that autophagy sensitizes cells to cadmium ions.
碲化镉（CdTe）和碲化镉/硫化镉/硫化锌（CdTe/CdS/ZnS）量子点均可诱导 PC12 和 HEK293 细胞发生类似水平的自噬，而前者表现出更高的毒性。低浓度的镉离子本身不足以诱导自噬或细胞毒性。有趣的是，镉离子与 CdTe/CdS/ZnS 的联合作用模拟了 CdTe 的毒性效应，表明自噬使细胞对镉离子敏感。
