Kali Arunava, Charles Mv Pravin, Noyal Mariya Joseph, Sivaraman Umadevi, Kumar Shailesh, Easow Joshy M
Department of Microbiology, Mahatma Gandhi Medical College & Research Institute, Pondicherry.
Australas Med J. 2013 Aug 31;6(8):387-91. doi: 10.4066/AMJ.2013.1709. eCollection 2013.
Candida species are emerging as a potentially pathogenic fungus in patients with broncho-pulmonary diseases. The synergistic growth promoting association of Candida and Mycobacterium tuberculosis has raised increased concern for studying the various Candida spp . and its significance in pulmonary tuberculosis patients during current years.
This study was undertaken with the objective of discovering the prevalence of co-infection caused by different Candida species in patients with pulmonary tuberculosis.
A total of 75 patients with pulmonary tuberculosis diagnosed by sputum Ziehl-Neelsen staining were included in the study. Candida co-infection was confirmed using the Kahanpaa et al. criteria. Candida species were identified using gram stain morphology, germ tube formation, morphology on cornmeal agar with Tween-80, sugar fermentation tests and HiCrome Candida Agar.
Candida co-infection was observed in 30 (40%) of patients with pulmonary tuberculosis. Candida albicans was the most common isolate observed in 50% of the patients with co-infection, followed by C. tropicalis (20%) and C. glabrata (20%). Candida co-infection was found in 62.5% of female patients, while it was observed in only 29.4% of the male patients (P value 0.0133). Mean ± SD age of the patients with C. glabrata infection was 65.83 ± 3.19, while the mean ± SD age of the patients with other Candida infections was 43.25 ± 20.44 (P value 0.0138).
Many patients with pulmonary tuberculosis have co-infection with Candida spp. The prevalence of non-albicans Candida species is increasing and may be associated with inadequate response to anti-tubercular drugs. C. glabrata infection has a strong association with old age.
念珠菌属正成为支气管肺部疾病患者中一种潜在的致病真菌。念珠菌与结核分枝杆菌的协同生长促进关联在近年来引发了对研究各种念珠菌属及其在肺结核患者中的意义的更多关注。
本研究旨在发现肺结核患者中不同念珠菌属引起的合并感染的患病率。
本研究纳入了75例经痰萋-尼氏染色确诊的肺结核患者。使用卡汉帕等人的标准确认念珠菌合并感染。通过革兰氏染色形态、芽管形成、含吐温-80的玉米粉琼脂上的形态、糖发酵试验和HiCrome念珠菌琼脂鉴定念珠菌属。
在30例（40%）肺结核患者中观察到念珠菌合并感染。白色念珠菌是合并感染患者中最常见的分离株，在50%的患者中出现，其次是热带念珠菌（20%）和光滑念珠菌（20%）。在62.5%的女性患者中发现念珠菌合并感染，而在男性患者中仅观察到29.4%（P值0.0133）。光滑念珠菌感染患者的平均年龄±标准差为65.83±3.19，而其他念珠菌感染患者的平均年龄±标准差为43.25±20.44（P值0.0138）。
许多肺结核患者合并念珠菌属感染。非白色念珠菌的患病率正在增加，可能与抗结核药物反应不足有关。光滑念珠菌感染与老年密切相关。
