Max Planck Institute for Biology of Ageing, Cologne, Germany ; Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
PLoS One. 2013 Sep 10;8(9):e74681. doi: 10.1371/journal.pone.0074681. eCollection 2013.
Dietary restriction (DR) can result in lifespan-extension and improved function and health during ageing. Although the impact of DR on lifespan and health has been established in a variety of organisms, most DR experiments are carried out on laboratory strains that have often undergone adaptation to laboratory conditions. The effect of DR on animals recently derived from wild populations is rarely assessed. We measured the DR response of four populations of Drosophila melanogaster within two generations of collection from the wild. All populations responded to DR with an increase in lifespan and a decrease in female fecundity, similarly to a control, laboratory-adapted strain. These effects of DR are thus not a result of adaptation to laboratory conditions, and reflect the characteristics of natural populations.
饮食限制（DR）可以延长寿命，并改善衰老过程中的功能和健康。尽管 DR 对寿命和健康的影响已经在各种生物中得到证实，但大多数 DR 实验都是在经过实验室条件适应的实验室品系上进行的。DR 对最近从野生种群中获得的动物的影响很少被评估。我们在从野外采集后的两代内，测量了四个黑腹果蝇（Drosophila melanogaster）种群对 DR 的反应。所有种群对 DR 的反应都是寿命延长和雌性生殖力下降，与对照的实验室适应品系相似。因此，DR 的这些影响不是对实验室条件适应的结果，而是反映了自然种群的特征。
