Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Biology (Basel). 2013 Jul 9;2(3):976-1033. doi: 10.3390/biology2030976.
This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, histone gene synthesis and nuclear RNA retention, has significant implications for gene regulation. These functional nuclear domains include the nucleolus, nuclear speckle, nuclear stress body, transcription factory, Cajal body, Gemini of Cajal body, histone locus body and paraspeckle. We herein review the roles of nuclear bodies in regulating gene expression and their relation to human health and disease.
本文综述了核体在调节基因表达中的作用。细胞过程的区室化，如核糖体生物发生、RNA 加工、细胞对应激的反应、转录、剪接体 snRNP 的修饰和组装、组蛋白基因合成和核 RNA 保留，对基因调控具有重要意义。这些功能性核域包括核仁、核斑点、核应激体、转录工厂、Cajal 体、Cajal 体的双子星、组蛋白基因座体和核周体。本文综述了核体在调节基因表达中的作用及其与人类健康和疾病的关系。
