Department of Urology, Qianfoshan Hospital Affiliated to Shandong University, No.16766 Jingshi Road, Jinan, Shandong Province, 250014, China.
Pathol Oncol Res. 2014 Jan;20(1):43-50. doi: 10.1007/s12253-013-9618-0. Epub 2013 Sep 17.
Prostate cancer is a big killer in many regions especially American men, and this year, the diagnosed rate rises rapidly. We aimed to find the biomarker or any changing in prostate cancer patients. With the development of next generation sequencing, much genomic alteration has been found. Here, basing on the RNA-seq result of human prostate cancer tissue, we tried to find the transcription or non-coding RNA expressed differentially between normal tissue and prostate cancer tissue. 10 T sample data is the RNA-seq data for prostate cancer tissue in this study, we found the differential gene is TFF3-Trefoil factor 3, which was more than seven fold change from prostate cancer tissue to normal tissue, and the most outstanding transcript is C15orf21. Additionally, 9 lncRNAs were found according our method. Finally, we found the many important non-coding RNA related to prostate cancer, some of them were long non-coding RNA (lncRNA).
前列腺癌是许多地区（尤其是美国男性）的一大杀手，今年，其诊断率迅速上升。我们旨在寻找前列腺癌患者的生物标志物或任何变化。随着下一代测序的发展，已经发现了许多基因组改变。在这里，基于人类前列腺癌组织的 RNA-seq 结果，我们试图在正常组织和前列腺癌组织之间找到差异表达的转录物或非编码 RNA。在这项研究中，10T 样本数据是前列腺癌组织的 RNA-seq 数据，我们发现差异基因是 TFF3-三叶因子 3，它在前列腺癌组织到正常组织中的变化超过七倍，最突出的转录本是 C15orf21。此外，根据我们的方法还发现了 9 个长链非编码 RNA（lncRNA）。最后，我们发现了许多与前列腺癌相关的重要非编码 RNA，其中一些是长链非编码 RNA（lncRNA）。
