Division of Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.
Department of Functional Biogerontology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Cancer Lett. 2018 Apr 1;418:159-166. doi: 10.1016/j.canlet.2018.01.012. Epub 2018 Jan 9.
Long non-coding RNA (LncRNA) is defined as an RNA transcript that does not encode any protein, with a length longer than 200 nt. Based on the recent advances in high-throughput sequencing techniques, a large number of lncRNAs have been characterized as functional transcripts that play important roles in various biological processes as well as pathologic states. In a research field of prostate cancer, several key lncRNAs have been identified as new players that contribute to the pathophysiology of the disease, which is primarily regulated by androgen and its cognate receptor. This review sheds light on the history and future perspective of these prostate cancer-associated lncRNAs.
长链非编码 RNA（lncRNA）被定义为一种不编码任何蛋白质的 RNA 转录物，其长度大于 200nt。基于高通量测序技术的最新进展，大量的 lncRNA 已被鉴定为具有重要功能的转录物，在各种生物过程以及病理状态中发挥作用。在前列腺癌的研究领域中，已经确定了几个关键的 lncRNA 作为新的参与者，它们有助于疾病的病理生理学，主要受雄激素及其同源受体调节。本综述探讨了这些与前列腺癌相关的 lncRNA 的历史和未来展望。
