软件自动化计数 Ki-67 增殖指数与滤泡性淋巴瘤的病理分级和疾病进展相关。
Software-automated counting of Ki-67 proliferation index correlates with pathologic grade and disease progression of follicular lymphomas.
机构信息
Dept of Pathology, The Johns Hopkins Medical Institutions, Weinberg 2242 Pathology, 401 N Broadway, Baltimore, MD 21231-2410;
出版信息
Am J Clin Pathol. 2013 Oct;140(4):579-87. doi: 10.1309/AJCPTMA1F6LWYTQV.
Abstract
OBJECTIVES
To examine the accuracy of software-assisted measurement of the Ki-67 proliferation index (PI) and its correlation with the grade and clinical progression of follicular lymphoma (FL).
METHODS
High-power field equivalents were extracted from H&E- and Ki-67-immunostained slides of FL, and a nuclear quantitation algorithm was used to calculate a PI. Representative fields were manually counted for validation with close agreement.
RESULTS
The PI was significantly higher in World Health Organization grade 3 FL than grade 1 to 2 FL. Disease progression, as defined by subsequent treatment with radiation or cytotoxic chemotherapy, was also significantly associated with elevated PI but not pathologic grade.
CONCLUSIONS
These data show that software-automated quantitation of Ki-67 can provide both a useful adjunct to pathologic grade in FL and improved prognostic information for patients.
摘要
目的
研究软件辅助测量 Ki-67 增殖指数（PI）的准确性及其与滤泡性淋巴瘤（FL）分级和临床进展的相关性。
方法
从 FL 的 H&E 和 Ki-67 免疫组化切片中提取高倍视野等价物，并使用核定量算法计算 PI。代表性视野进行手动计数以验证，结果非常一致。
结果
与 1 至 2 级 FL 相比，WHO 分级 3 的 FL 的 PI 明显更高。如随后采用放疗或细胞毒化疗进行治疗所定义的疾病进展，也与升高的 PI 显著相关，但与病理分级无关。
结论
这些数据表明，Ki-67 的软件自动定量不仅可以为 FL 的病理分级提供有用的辅助，还可以为患者提供更好的预后信息。
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